肽基脯氨酰顺反异构酶Pin1与肿瘤发生发展的研究进展

Recent advances in research of peptidyl-prolyl cis-trans isomerase Pin1 in tumor

目的:总结肿瘤中肽基脯氨酰顺反异构酶Pin1的研究进展。方法:以Pin1和肿瘤为关键词,检索1979-01～2008-01PubMed和中国医学文献数据库的文献。纳入标准:1)关于Pin1在肿瘤信号通路中的调节作用的研究;2)关于Pin1促进肿瘤发生发展的研究。资料初选后,根据纳入标准,本文共综述了32篇英文文献和1篇中文文献。结果:肽基脯氨酰顺反异构酶Pin1能特异性地识别磷酸化的丝/苏-脯氨酰基序,调控磷酸化蛋白的功能。肽基脯氨酰顺反异构酶Pin1在细胞信号通路的调节和肿瘤发生发展方面的有重要作用。结论:Pin1在肿瘤的发生和发展中扮演重要角色,这为肿瘤的诊断和治疗提供了新的视野,但还需要进一步的研究。

OBJECTIVE： To review the recent advances in research of peptidyl prolyl cis trans isomerase Pin1 in tumor, METHODS： Searched on CBM disc and PubMed by the keyword＂Pin1 and tumor＂ to get the article about Pin1 in tumor research during 1979-01-2008-01. The included criteria： 1） about Pin1 regulation in tumor signaling; 2） about Pin1 on tumorigenesis. After primary selection by the included criteria, 32 papers in English and a paper in Chinese were summarized. RESULTS： Peptidyl prolyl cistrans isomerase Pin1 specifically binds the motif of phosphorylation of Ser/Thr-Pro and regulates the function of phosphorylated proteins. Pin1 is related with the occurrence of tumour and the regulation cell signaling. CONCLUSION： Pin1 plays a critical role in tumorgenesis and sheds a new light in tumor diagnosis and therapy and more studies are needed.