nm23和CD44v6蛋白在非小细胞肺癌中的表达及其临床意义

The expressions of nm-23 and CD44v6 protein in non-small cell lung cancer and their clinical significance

目的:探讨nm23与CD44v6蛋白在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其临床意义。方法:采用免疫组织化学法检测58例NSCLC标本中nm23、CD44v6的表达情况。结果:nm23阳性率为87.9%(51/58),其中T1～T2组与T3～T4组间差异有统计学意义(P<0.05)。CD44V6阳性率为55.2%(32/58),其中鳞癌阳性率(85.7%)明显高于腺癌(24%),P<0.05;中分化组阳性率(71.9%)高于低分化组(44.4%)和高分化组(35.3%),P<0.05。nm23、CD44V6的表达与pTNM分期、淋巴结转移及生存率之间无相关性,P>0.05。结论:nm23和CD44v6蛋白表达分别与NSCLC原发肿瘤大小(T)、病理类型、分化程度存在相关性,与pTNM分期及淋巴结是否转移无相关性。

Objective：To study the expressions of nm23 and CD44v6 proteins in non-small cell lung cancer （NSCLC） and their clinical significance. Methods： Expressions of nm23 and CD44v6 proteins were detected in 58 cases with NSCLC by two-step immuno- histochemistry. Results：The overall positive rate of nm23 staining was 87.9% （51/58）. There was a significant difference between T1- T2 group and T3-T4 group （ P 〈 0.05 ）. The overall positive rate of CD44v6 was 55.2% （32/58）. It was significantly higher in squamous cell carcinoma than that in adenocarcinoma （85.7% vs 24%, P 〈 0.05 ） and significantly higher in moderate differentiated group than that in poor- and well-differentiated group （71.9% vs 44.4% and 35.3%, P 〈0.05）. The expressions of nm23 and CD44v6 were not associated with pTNM stage, lymph node metastasis, and survival rate （ P 〉 0.05 ）. Conclusion： The expressions of nm23 and CD44v6 correlated with the tumor size, pathological classification, differentiation degree of NSCLC but had no relation with pTNM stage and lymphnode metastasis.