摘要
目的:探讨nm23与CD44v6蛋白在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其临床意义。方法:采用免疫组织化学法检测58例NSCLC标本中nm23、CD44v6的表达情况。结果:nm23阳性率为87.9%(51/58),其中T1~T2组与T3~T4组间差异有统计学意义(P<0.05)。CD44V6阳性率为55.2%(32/58),其中鳞癌阳性率(85.7%)明显高于腺癌(24%),P<0.05;中分化组阳性率(71.9%)高于低分化组(44.4%)和高分化组(35.3%),P<0.05。nm23、CD44V6的表达与pTNM分期、淋巴结转移及生存率之间无相关性,P>0.05。结论:nm23和CD44v6蛋白表达分别与NSCLC原发肿瘤大小(T)、病理类型、分化程度存在相关性,与pTNM分期及淋巴结是否转移无相关性。
Objective:To study the expressions of nm23 and CD44v6 proteins in non-small cell lung cancer (NSCLC) and their clinical significance. Methods: Expressions of nm23 and CD44v6 proteins were detected in 58 cases with NSCLC by two-step immuno- histochemistry. Results:The overall positive rate of nm23 staining was 87.9% (51/58). There was a significant difference between T1- T2 group and T3-T4 group ( P 〈 0.05 ). The overall positive rate of CD44v6 was 55.2% (32/58). It was significantly higher in squamous cell carcinoma than that in adenocarcinoma (85.7% vs 24%, P 〈 0.05 ) and significantly higher in moderate differentiated group than that in poor- and well-differentiated group (71.9% vs 44.4% and 35.3%, P 〈0.05). The expressions of nm23 and CD44v6 were not associated with pTNM stage, lymph node metastasis, and survival rate ( P 〉 0.05 ). Conclusion: The expressions of nm23 and CD44v6 correlated with the tumor size, pathological classification, differentiation degree of NSCLC but had no relation with pTNM stage and lymphnode metastasis.
出处
《肿瘤》
CAS
CSCD
北大核心
2008年第7期609-612,共4页
Tumor