多层螺旋CT鼻咽癌灌注研究

The primary report of multi-slice helical CT perfusion imaging in nasopha-ryngeal carcinoma

目的:探讨鼻咽癌多层螺旋CT灌注成像的价值。方法:采用Siemens Emotion6多层螺旋CT机对22例鼻咽癌,l1例鼻咽炎症及20例无鼻咽疾病患者进行鼻咽灌注扫描,用其专用灌注软件perfusion灌注软件分别测量血流量(blood flow,BF)、血容量(blood volume,BV)、峰值时间(time to peak,TP)等指数,以评价鼻咽癌的血流动力学改变及其规律性。结果:鼻咽癌组BF、BV、TP95%可信区间分别为131.29～178.98ml/(min·100g),20.30～27.18ml/100g,19.77～25.60s,鼻咽炎症BF、BV、TP95%可信区间分别为(78.66±29.56)ml/(min·100g),(15.66±11.87)ml/100g,19.01～29.17s,正常对照组BF、BV、TP95%可信区间分别19.02～33.39ml/(min·100g),4.58～7.59ml/100g,18.00～25.20s。鼻咽癌、鼻咽炎症及对照组BF、BV统计学有显著性差异。结论:CT灌注成像可用于评价鼻咽癌及鼻咽炎血流灌注情况,有助于鼻咽癌的鉴别诊断及制定治疗方案。

Objective： To study the parameters of CT perfusion imaging of nasopharyngeal cancer（NPC）. Methods：CT perfusion imaging of nasopharynx was obtained in 53 individuals, including 22 patients with NPC, 11 cases of inflammation and 20 control subjects.Perfusion parameters such as blood flow（BF）,blood volume（BV）and time to peak（TP） were calculated. Results： The 95% confidence intervals of BF, BV and TP of NPC group were 131.29-178.98 ml（min·100 g）, 20.30-27.18 ml/100 g,19.77-25.60 s, that of inflammation group was（78.66±29.56） ml/（min·100 g）, （15.66±11.87） ml/100 g, 19.01-29.17 s and that of control group was 19.02-33.39 ml/（min·100 g）, 4.58-7.59 ml/100 g, 18.00-25.20 s. The value of BF and BV had significant difference between NPC, inflammation and control group.Conclusion：CT perfusion imaging can be a new method to evaluate the blood supply of NPC.