赖脯胰岛素的临床应用研究

Study on the clinical use of insulin lispro

目的:评价赖脯胰岛素(Lispro)对糖尿病患者的疗效与安全性。方法:2007年1～11月对我院的57例糖尿病患者用赖脯胰岛素治疗前后测定血糖、糖化血红蛋白,并记录赖脯胰岛素用量、低血糖发生率。结果:治疗3个月后,患者的空腹血糖、餐后2h血糖、HbA1c均明显下降;赖脯胰岛素日总量与治疗前重组人胰岛素相同或略减少,低血糖发生率明显减少。结论:赖脯胰岛素在改善糖尿病患者的血糖控制的同时低血糖发生率低,安全而且患者依从性好。

Objective： To evaluate the efficacy and safety of insulin lispro in the treatment of diabetic patients. Methods： Blood glucose, HbAle, dose of insulin lispro and incidence of hypoglycemia were assessed in 57 patients with diabetes, before and after treatment with insulin lispro, during the period from January to November 2007. Results： Three months after treatment with insulin lispro, fasting blood glucose, 2 h postprandial glucose and HbA1c were significantly lower, compared with baseline. The total daily dose of insulin lispro is similar with or slightly less than that of previously used recombinant human insulin; meanwhile, the incidence of hypoglycemia significantly decreased. Conclusion： Insulin lispro provides better glyeemie control with lower incidence of hypoglycemia, and so compliance, of the diabetic patients.