L-肉碱治疗肾性贫血的临床分析

Clinical Analysis of L-carnitine on Renal Anemia

目的观察L-肉碱在尿毒症肾性贫血治疗中的作用。方法将63例尿毒症患者,随机分成治疗组及对照组,两组患者均皮下注射促红细胞生成素6000u,2次/周,口服右旋糖酐铁75mg,每天3次,治疗组每次血液透析结束时静脉注射L-肉碱2g,2次/周,共3个月;对照组静脉注射等量注射用水。结果治疗组患者血HCT、Hb上升幅度明显高于对照组(P<0.05或P<0.01),治疗组患者体力、精神状态、食欲、心累、睡眠障碍、注意力不集中、呼吸困难、透析耐受性等症状的改善十分显著(P<0.05)。结论尿毒症患者补充L-肉毒碱可增加红细胞膜的稳定性,改善对促红细胞生成素的敏感性,减少促红细胞生成素的用量,提高其疗效。

Objective To assess the efficacy of maintenancehemodialysis patients with anemia treated with L-carnitine. Methods Sixty three maintenance hemodialysis patients were randomly divided into 2 groups：treatment group and control group. Two groups were treated by rHuEPO（6000u,two times each week by subcutaneous injection）and oral iron dextran（75mg,three times each day）. In treatment group,2g of L-carnitine was infused after each hemodialysis treatment,two times each week, for 3 months. In control group, equivalence water for injection each time. Results Compared with the control group, HCT and Hb were all significantly increased in treatment group（P 〈 0.05 or P 〈 0.01 ）; The improvement of clinical symptoms of acratia, mental status, appetite, congestive heart tried, sleep disorders, inattention, dyspnea, tolerance to hemodialysis muscle spasmwere obvious （P〈 0.05）. Conclusion Intravenous treament of L-carnitine may elevate stability of erythrocyte membrane and improve the sensitive of EPO,is safe and effective in maintenance hemodialysis patients.