摘要
目的观察S100A9、Galectin-7在放疗敏感性不同宫颈癌组织中的表达及意义。方法收集治疗前宫颈癌组织标本,病理诊断均为中分化鳞癌,在进行放疗后根据WHO实体瘤放疗疗效判断标准,从中选择60例对放疗敏感的病例(高敏感组)和35例对放疗不敏感的病例(低敏感组)应用免疫组织化学方法检测组织中这些蛋白的表达。结果免疫组化结果显示S100A9、Galectin-7的表达强度和表达率在高敏感组中均高于低敏感组。结论S100A9和Galectin-7与宫颈癌放疗敏感性有关。
Objective To investigate significance and expression of S100A9,Galectin-7 in cervical carcinoma tissues with different radiotherapy sensitivity. Methods Neoplasmic tissues were collected from untreated cervical carcinoma patients. The tissues were classified into two groups: high sensitivity group(HS) including 60 cases and low sensitivity group(LS) including 35 cases,according to their response to radiotherapy(WHO Standard). S100A9 and Galectin-7 expression were assayed by immunohistochemical method. Results It was found that the higher expression of S100A9 and Galectin-7 in HS group by immunohistochemical method. Conclusion S100A9,Galectin-7 expression were assocaited with radiotherapy sensitivity.
出处
《中国现代医生》
2008年第19期34-35,F0003,共3页
China Modern Doctor
关键词
宫颈癌
放疗敏感性
免疫组织化学
Cervical carcinoma
Radiotherapy sensitivity
Immunohistochenmical method