Galectin-7、S100A9放疗敏感性不同宫颈癌组织中表达的免疫组织化学研究

A Study on Expression of S100A9,Galectin-7 in Cervical Carcinoma Tissues with Different Radiotherapy Sensitivity

目的观察S100A9、Galectin-7在放疗敏感性不同宫颈癌组织中的表达及意义。方法收集治疗前宫颈癌组织标本,病理诊断均为中分化鳞癌,在进行放疗后根据WHO实体瘤放疗疗效判断标准,从中选择60例对放疗敏感的病例(高敏感组)和35例对放疗不敏感的病例(低敏感组)应用免疫组织化学方法检测组织中这些蛋白的表达。结果免疫组化结果显示S100A9、Galectin-7的表达强度和表达率在高敏感组中均高于低敏感组。结论S100A9和Galectin-7与宫颈癌放疗敏感性有关。

Objective To investigate significance and expression of S100A9,Galectin-7 in cervical carcinoma tissues with different radiotherapy sensitivity. Methods Neoplasmic tissues were collected from untreated cervical carcinoma patients. The tissues were classified into two groups： high sensitivity group（HS） including 60 cases and low sensitivity group（LS） including 35 cases,according to their response to radiotherapy（WHO Standard）. S100A9 and Galectin-7 expression were assayed by immunohistochemical method. Results It was found that the higher expression of S100A9 and Galectin-7 in HS group by immunohistochemical method. Conclusion S100A9,Galectin-7 expression were assocaited with radiotherapy sensitivity.