圆柱型土元对高脂血症小鼠脂肪代谢的影响

The Effect of Columnar Eupolyphaga Sinensis Walker on Lipid Metabolism in Hyperlipidemic Mice

土元是我国传统医学中常用的原料,圆柱型土元是苏土元在养殖过程中发现的变异品种。本研究分析了圆柱型土元的一般营养成分,并用圆柱型土元对高脂血症模型小鼠进行降血脂活性评价。Balb/c雄性小鼠分别喂食标准饲料、1%胆固醇饲料和含10%圆柱型土元粉末的1%胆固醇饲料3周,分析了圆柱型土元对小鼠空腹血脂和肝脏脂肪浓度的影响。结果显示,圆柱型土元可降低高血脂小鼠血液中总胆固醇(P<0.05)、甘油三酯浓度(P<0.001)、低密度脂蛋白胆固醇浓度(P<0.05),提高血液高密度脂蛋白胆固醇水平(P<0.05)、降低动脉硬化指数(P<0.001)。同时,圆柱型土元可降低高血脂小鼠肝脏甘油三酯浓度(P<0.001)。本研究结果提示,圆柱型土元可能会对由高血脂引发的动脉粥样硬化和高脂肪饮食造成的脂肪肝具有一定的预防和治疗作用。

Columnar Eupolyphaga sinensis walker（CEW） is a mutant Eupolyphaga sinensis walker which is an important material in traditional Chinese medicine. In this study, the composition of nutritional compounds and the activity of CEW were analyzed. Male Balb/C mice were fed for 3 weeks with standard diet, 1% cholesterol diet and 10 % CEW containing 1% cholesterol diet. The results found that CEW decreased the concentrations of serum total cholesterol（P〈0.05）, LDL cholesterol（P〈0.05） and triglyceride（P〈0. 001） in hyperlipidemic mice, while CEW increased the serum HDL cholesterol level（P〈0.05） and reduced the atherosclerosis index（P〈0. 001） in mice. On the other hand, CEW decreased the concentration of hepatic triglyceride in mice （P〈0.001）. These results suggested that the CEW may play a role in the treatment and prevention of hypolipidemia and fatty liver.