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基因Foxm1b在细胞增殖和肿瘤发生中的意义 被引量：4

Significance of Forkhead Box m1b(Foxm1b) Gene in Cell Proliferation and Carcinogenesis
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摘要 Foxm1b属Fox转录因子的一个亚型,在所有正在扩增的细胞中都能检查到,但到了细胞终末分化时则消失。Foxm1b与肝细胞的生长关系密切,主要通过抑制细胞周期素依赖性激酶(cyclin-dependent kinase,Cdk)的抑制剂介导细胞增殖,还参与生长激素(growth hormone,GH)介导的细胞增殖,但不会诱发肿瘤。Foxm1b在许多肿瘤细胞系和恶性肿瘤中均有表达,它可能是多种肿瘤增殖所必需的一种原癌基因。Foxm1b在肝切除、肝衰竭、肝移植等原因引起的肝再生中可能有治疗作用,是一个潜在的治疗人类肝细胞型肝癌(HCC)的新靶点。 Forkhead Box mlb （Foxm1b） is a subtype of the Fox transcription factor family. It is detected in all proliferative cells, but disappears when cells enter into their terminal differentiation phase. Foxm1b is closely related to hepatocellular growth, mainly through inhibiting cyclin-dependent kinase （CDK） inhibitors to influence cell proliferation. It also participates in growth hormone （GH） mediated cell multiplication, but does not induce tumors. The expression of Foxm1b has been observed in many tumor cell lines and malignant tumors, indicating that it might be an essential proto-oncogene in carcinogenesis. Furthermore, Foxm1b may take part in liver regeneration after hepatectomy, hepatic failure and liver transplantation. Foxm1b is a new potential target for the treat ment human hepatic cell carcinoma （HCC）.
作者 唐双意 焦杨 黎乐群
机构地区 广西医科大学第一附属医院药剂科 广西医科大学药学院 广西医科大学第一附属医院肝胆血管外科
出处 《癌症》 SCIE CAS CSCD 北大核心 2008年第8期894-896,共3页 Chinese Journal of Cancer
关键词 Foxm1b 细胞增殖 肿瘤发生 Foxmlb Cell proliferation Carcinogenesis
分类号 R730.2 [医药卫生—肿瘤]
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参考文献25

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癌症
2008年 第8期

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