痢疾杆菌51株耐药性分析

Analysis to drug resistance of Dysenteric bacilli:A report of 51 cases

目的:观察痢疾杆菌的耐药性,指导临床医师选择合理、有效的抗生素。方法:选择细菌性痢疾患者分离出的痢疾杆菌51株,K-B法检测细菌的药物敏感性。结果:痢疾杆菌对磺胺甲口恶唑、氨苄西林、诺氟沙星、头孢曲松等抗生素有较高的耐药性,耐药率分别为78.4%、60.8%、29.1%及23.5%;而对阿米卡星、磷霉素、氧氟沙星、哌拉西林、头孢哌酮及呋喃唑酮等抗生素较敏感,敏感性分别为78.4%、88.2%、84.3%、86.3%、92.2%及94.1%。结论:痢疾杆菌对磺胺甲口恶唑、氨苄青霉素及诺氟沙星耐药性较高,临床使用无效,而对三代头孢菌素、磷霉素、阿米卡星及氧氟沙星等敏感,可用于细菌性痢疾的治疗;另外呋喃唑酮对痢疾杆菌的敏感性明显增加,可以选用。

Objective：To study the drug resistance of Dysenteric bacilli so as to guide the physicians to choose effective antibiotics. Methods：Dysenteric bacilli were isolated from the stools of 51 patients, and Kirby-Bauer method was used to test their sensitivity to antibiotics. Results： Dysenteric bacilli were highly resistant to sulfamethoxazole （ 78.4% ）, ampicillin （ 60.8% ）, norfloxacin （ 29.1% ） and ceftriaxone （ 23.5% ）, but were sensitive to amikacin （ 78.4% ）, phosphonomycins （ 88.2% ）, ofloxacin （ 84. 3% ）, piperacillin （86.3%）, cefoperazone（92.2% ） and furazolidone （94.1% ）. Conclusions ： Dysenteric bacilli is highly resistant to sulfamethoxazole, ampicillin and norfloxacl, but sensitive to the third generation cephalosporins, phosphonomycins, amikacin and ofloxacin. Furazolidone is another chioce,for its sensitivity to Dysenteric bacilli is greatly increasing.