癫痫患者情感障碍和认知功能障碍的关系及其影响因素的研究

Research of the Relationship Between the Emotion Disorder and Cognitive Function Impairment Relation and its Influence Factors with the Epilepsy Patients

目的研究和探讨癫痫患者情感障碍和认知障碍的关系以及人口学因素和生活质量对认知障碍和情感障碍的影响。方法收集湛江中心人民医院神经内科门诊和住院的癫痫患者320例,正常对照组56例。分别进行韦氏智能测定,然后进行统计分析。结果320例癫痫患者中,智能水平低于正常者(IQ<90分)259例(80.9%),智能水平明显低下者(IQ<70分)168例(52.8%)。秩和检验结果显示单药服药组之间的认知水平和焦虑抑郁情感评分无显著差异,但联合用药组的认知水平明显低下,焦虑抑郁评分明显增高,丙戊酸钠+妥泰+卡马西平组的认知功能水平最低,而焦虑抑郁评分也最高。进行多元逐步线形回归检验,结果显示患者职业不同、文化程度不同、病程长短、发作次数多少以及是否存在脑部继发性疾病等则对患者的认知功能和焦虑抑郁情感影响显著。相关分析显示认知功能水平与患者的焦虑抑郁情感评分呈显著负相关,与患者的情绪、精力、认知功能、用药顾虑显著相关,而患者的焦虑抑郁情绪与其情绪、精力、认知功能显著相关。结论癫痫患者认知障碍和焦虑抑郁情感障碍是多种因素交互或综合作用的结果,其认知障碍和情感障碍相互影响,互为因果,且严重影响患者的生存质量。提高患者和家属对癫痫的认知,提到患者的文化素质,对降低癫痫后认知功能障碍和情感障碍,提高患者的生存质量至关重要。

Objective To study the relationship between the emotion disorder and cognitive function impairment relation and its in-fluence factors with the epilepsy patients. Methods We collected 320 cases epilepsy patients in hospital and 56 cases contrast normally in People＇s Hospital of the centre of Zhanjiang, and Carry on the determine of the cognitive function separately, the determine of the emotion status, and the measurement for the quality of life, then carry on statistical analysis. Results In 320 cases with epilepsy patients, 259 cases persons has intellectual Impairment （80.9%） （IQ〈90） , 168 cases has seriously intellectual Impairment （52.8%） （IQ〈70）. Cognitive impairment in both group are significance differences between normal group and the epilepsy patients. There is not remarkable difference in cognitive level and anxious depressed emotion on the single anti-epilepsy drugs of the three groups, but both and three anti-epilepsy medicines therapeutic alliance might induced the severity cognitive impairment and anxious depressed emotion disorder with epilepsy patients. Regression analysis result, the main influence factor of the cognitive impairment is education and job, the influence of the age and sex is not remarkable. The profession, education, course of disease, episode frequency and secondary encephalopathy disease are remarkable influence on the cognitive impairment and the anxious-depressed emotion disordor. Relevant analysis shows that the cognitive function level and the anxious depressed emotion display obviously negativity correlation, that are remarkable correlation with the patient＇s mood , stamina , cognitive function , worry of using medicine, and the patient＇s anxious depressed disorder have remarkable correlation with the patient＇s mood , stamina , cognitive function, too. Conclusion It is the influence each other and combination effect of many kinds factors on the cognitive impairment and the anxious depressed emotion disorder. It is essential to improve the patient＇s survive quality and to reducing the cognitive impairment and emotion disorder after epilepsy through Improve the cognition function of the epilepsy patients and elevate the patient＇s culture diathesis.