莫沙必利与多潘立酮治疗糖尿病性胃轻瘫的疗效比较

The Comparative Research on Curative Effect of Mosapride and Domperidone on Treating Gastroparesis Diabeticorum (DGP)

目的探讨胃肠动力药物莫沙必利与胃动力药多潘立酮治疗糖尿病性胃轻瘫的疗效对比。方法52例确诊为糖尿病性胃轻瘫患者随机分为两组,莫沙必利组和多潘立酮组,治疗4周后观察药物的临床疗效、胃固体排空时间变化和不良反应。结果莫沙必利治疗糖尿病性胃轻瘫疗效明显好于多潘立酮,两组比较临床总有效率有显著性差异(P<0.05)。莫沙必利能明显缩短糖尿病性胃轻瘫患者胃固体排空时间(P<0.01),多潘立酮也缩短胃固体排空时间(P<0.05)。两组不良反应轻微。结论莫沙必利治疗糖尿病性胃轻瘫疗效明显,优于多潘立酮,不良反应小,有较好的临床应用价值。

Objective To contrast the curative effect of mosapride with that of domperidone on gastroparesis diabeticorum （DGP）. Methods 52 DGP definite patients were divided into two groups randomly, mosapride group and domperidone group. The clinical effect and the change and untoward effect of gastric emptying time of this two medicines were observed after treatment for four weeks＇. Results The curative effect of mosapride in treating DGP was obviously better than that of domperidone The total clinical effective rate between this two groups showed significant difference （P 〈 0.05）. Mosapride could significantly shorten the gastric emptying time of DGP patients （P 〈0.01） and domperidone could also shorten the time （P 〈0.05）. The advevse effects in the two groups were mild. Conclusion The curative effect of mosapride in treat DGP was better than domperidone with light advorse effect was and has good value in clinical application.