卵磷脂花粉对实验性高血脂大鼠的降血脂效应及其机制研究

Study of the Effect and Functional Mechanism of Pine Pollen on Reducing the Blood-fat Level of the Experimental Mice

目的研究卵磷脂花粉对高血脂模型动物血脂的影响。方法建立大鼠高脂模型,试验前检测血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)含量。根据TC、TG和HDL-C水平及体重随机分成5组:阴性对照组、高脂模型组和1.25、2.50、3.75g/kg3个剂量组,预防性给予卵磷脂花粉30天,再次检测TC、TG和HDL-C含量。结果与模型对照组比较,卵磷脂花粉中、高剂量组TC降低,高剂量组TG降低,高剂量组HDL-C升高,差异有显著性。结论卵磷脂花粉对模型大鼠有良好的降低血清TC、TG的作用,对实验性高血脂的形成具有一定的预防控制效应。

Objective To study the effect of lecithin pollen on hyperlipidemia model experimental animals. Methods Mice were feed with high - fat feeds in order to establish the hyperlipidemia models. The contents of TC ,TG and HDL - C in the serum of the mice were tested before the experiment and the mice were divided into 5 groups according to their TC level, induding the control group, the model group and 1.25,2.50and 3.75g/kg lecithin pollen groups. Lecithin pollen was given preventively for 30 days, and then the TC,TG and HDL-C level of the mice were retested. Results Compared with the model group, the TC level of the middle and high dose group decreased. The TG level of the high dose group also decreased and the HDL-C level of the high dose group increased. The difference was significant. Conclusion The lecithin pollen is effective in preventing the formation of hyperlipidemia in the experimental mice.