老年高血压病患者尿转铁蛋白独立相关因素的研究

Associated Factors of Urinary Transferrin in Aged Patients with Essential Hypertension

目的通过筛选老年高血压病患者尿转铁蛋白（TRF）的独立相关因素，寻找减少老年高血压病患者尿TRF排泄的途径。方法对617例老年高血压病患者进行问卷调查、24h动态血压检测、实验室检查和尿TRF检测，运用Logistic回归分析方法筛选影响老年高血压病患者尿TRF排泄的相关因素。结果老年高血压病患者尿TRF排泄的独立相关因素有高血压病程（OR=1．019，95％CI：1．001-1．037，P〈0．05）、24h收缩压（OR=1．044，95％CI：1．027-1．061，P〈0．001）、低密度脂蛋白胆固醇（OR=0．339，95％CI：0．145～0．533，P〈0．05）和年龄（OR=1．064，95％CI：1．004～1．127，P〈0．05）。结论积极采取有效措施，防治高血压，降低低密度脂蛋白胆固醇的水平，可能是减少老年高血压病患者尿TRF排泄的重要途径。

Objective To find the ways to decrease urinary transferrin （TRF） by analysing its associated factors in aged patients with essential hypertension（EH）. Methods A cross - sectional survey was conducted comprising a sample of 617 aged patients with EH. The questionnaire contains items on physical examination,24-h ambulatory blood pressure monitoring,laboratory measurement and TRF measurement. Univariate analyses and multivariate analysis were applied to discover associated factors of TRF. Results Independent as- sociated factors of TRF included the course of EH （ OR = 1.019,95 % CI： 1.001 - 1. 037, P 〈 0.05 ） ,24hSBP （ OR = 1. 044,95 % CI： 1. 027 1. 061, P 〈0. 001 ） , low density lipoprotein-cholesterol（ OR = 0. 339,95 % CI： 0. 145 - 0. 533, P 〈 0.05 ） and age （ OR = 1. 064,95% CI： 1. 004 - 1. 127,P 〈 0.05 ）. Conclusion Taking effective measures to prevent and control EH, and lowering the level of, LD1 may be the main way to reduce TRF in aged patients with EH.