NADPH氧化酶源性的活性氧在胚胎干细胞分化成心肌细胞的分子机制中的作用

Role of NADPH Oxidases Derived Reactive Oxygen Species in Differentiation of Cardiomyocytes from Embryonic Stem Cells

活性氧(reactive oxygen species,ROS)主要包括超氧离子(O2-),过氧化氢(H2O2)和羟自由基(OH-),在心肌细胞中,ROS的产生主要来自膜结合的NADPH氧化酶(NOX)的催化作用,并作为第二信使通过相关信号传导途径双向调节细胞的增殖与死亡。,最近发现ROS在胚胎干细胞(embryonic stem cells,ES)向心肌细胞分化过程中起重要的调节作用。对这些调节机制的研究有利于我们更好地认识ROS及NADPH氧化化酶在心肌细胞分化中的重要作用并有利于我们确定促进心脏分化的因子。

The most common reactive oxygen species （ROS） include superoxygen anion （O2^- ）, peroxides （H2O2 ） , and hydroxyl free radicals （OH-） . In cardiomyocytes, ROS are generated mainly due to the catalyzation of the membrane-bound NADPH oxidase （ NOX）, and have potential to alter the balance between cell growth and cell death via relevant signaling pathways. Recently, ROS have been demonstrated to play a critical role in regulating differentiation of embryonic stem cells into cardiomyocytes. Research in the regulation mechanisms of ROS will contribute to our understanding of the role of ROS and NADPH oxidase in cardicomyocyte differentiation and help to identify the factors capable of promoting cardiac differentiation.