血红蛋白水平对中晚期宫颈癌放疗效果的临床研究

Impact of Blood Hemoglobin Level on the Result of Radiotherapy for Middle Advanced Cervical Carcinoma

目的:探讨中晚期宫颈癌放射治疗后近期、远期疗效与血红蛋白水平的关系。方法:1996年2月至2001年12月159例病理证实的中晚期宫颈癌患者在我科接受根治性放疗,体外照射采用60Co远距离体外治疗机,先行全盆腔野照射40Gy/20次,再行中央遮盖野16Gy/8次,腔内后装放疗192Ir(24-32)Gy/(3-5)次。放疗前中后测定血红蛋白含量,按治疗前血红蛋白水平分成正常,轻、中、重度贫血4组。结果:所有患者均随访,随访率90.6%,放疗中持续中重度贫血对中晚期宫颈癌的局部控制率和远期疗效有明显影响。结论:纠正贫血有助于宫颈癌的局部控制及提高远期疗效。

Objective： To determine the impact of blood hemoglobin level on the radiotherapy results of middle advanced cervical carcinoma. Methods： From February 1996 to December 2001, 159 patients with middle advanced cervical carcinoma underwent radiotherapy. They received external beam radiotherapy with ^60Co 40Gy/20 fractions to pelvic field and 16Gy/8 fractions to four fields of pelvis. At the same time, they also received after loading radiotherapy with 192Ir（24-32） Gy/（3-5） fractions on point A. The peripheral blood hemoglobin concentration for all patients was measured before, during and after radiotherapy. These patients were divided into four groups according to the peripheral blood hemoglobin concentration before radiotherapy. They were normal blood hemoglobin concentration, or light, middle and severe anemia. Resuits： All patients were followed with a follow-up rate of 90.6%. There were significant effects for middle advanced cervical carcinoma who were with middle and heavy anemia. Conclusion： The improvement of anemia condition may be a worthwhile strategy for radiation treatment to improve local control and survival rate.