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压力性尿失禁大鼠耻尾肌功能变化的实验研究 被引量：1

Experimental research on functional and structural changes of pubococcygeus in rats with stress urinary incontinence
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摘要 目的探索压力性尿失禁(SUI)大鼠耻尾肌结构改变情况,以探讨和评价含低指标时盆低肌肉中的异常变化。方法利用免疫组化方法检测压力性尿失禁大鼠与正常大鼠盆底耻尾肌中神经肽Y(neuropeptide Y,NPY)、血管活性肠肽(vasoactive intestinal peptide,VIP)和α-肌动蛋白的变化,并用计算机图象扫描对其进行量化和统计。结果免疫组化图象分析示SUI模型大鼠与正常对照相比较,耻尾肌中的α-肌动蛋白、VIP和NPY明显减少。结论SUI时盆底肌肉功能障碍与VIP、NP和Y肌动蛋白的减少有关。 Objective To investigate the functional and structural changes of pubococcygeus in rats with stress urinary incontinence （SUI）.Methods The expression of neuropeptide Y （NPY）, vasoactive intestinal peptide （VIP） and α-actin in pubococcygeus muscles of both SUI and normal rats were examed by immunohistochemical staining. The results were analyzed by scaning images and semiquantitative evaluation. Results The immunoreactivity score of α-actin, VIP and NPY in model rats were signifigantly lower than those of control group （ P 〈 0.05）. Conclusion The reduction of α-actin, VIP and NPY was related to the muscle dysfunction of pelvicfloor when SUI happened.
作者 蒋玉清 李文平
机构地区 河北医科大学第三医院泌尿外科
出处 《河北医药》 CAS 2008年第8期1098-1100,共3页 Hebei Medical Journal
关键词 压力性尿失禁 神经肽Y 血管活性肠肽 Α-肌动蛋白 stress urinary incontinence neuropeptide Y vasoactive intestinal peptide α-actin
分类号 R969.3 [医药卫生—药理学] R694.54 [医药卫生—泌尿科学]
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参考文献15

  • 1孙智晶,朱兰,陈杰,郎景和.压力性尿失禁的病因学研究[J].疑难病杂志,2004,3(2):65-68. 被引量：5
  • 2Hollabaugh RS, Steiner MS, Dmochowski RR. Neuroanatomy of the female continence complex: clinical implications. Urology,2001,57 : 382.
  • 3Onuoha GN, Nicholls DP. Regulatory peptides in the heart and major vessels of man and mammals. Neuropeptides, 1999,33 : 165.
  • 4McDermott BJ, Millar BC. Cardiovascular effect of neuropeptide Y: receptor interactions and cellular mechanisms. Cardiovascular Res, 1993,27 : 893.
  • 5Rogausch H, Delrey A, Kabiersch A. Endotoxin impeds vasconstriction in spleen:role of endogenous interleukin-1 and sympathetic innervation. Am J Physiol, 1997,272 : 2048.
  • 6Said S, MuttV.Ploypeptide with broad biological activiry: isolation from small intes tione. Science, 1970,169:1217-1218.
  • 7Lundberg JM, Rudehill A, Sollev A, et al. Frequency and reserpine dependent chemical coding of sympathetic transmission: differential release of noradrenaline and neuropeptide Y from pig spleen. Neurosci Lett, 1986, 63: 96- 100.
  • 8田建平.女性盆底功能障碍性疾病研究进展[J].河北医药,2007,29(2):163-164. 被引量：13
  • 9Smith AR, Hosker GL, Warreu DW. 33ac role of pudendal nerve damage in the aetiology of genuine stress incontinence in women. Br J Obstet Gynaecol, 1989,96: 29-32.
  • 10Busacchi P, Giorgio R. A histological and immunohistochemical study of neuropeptide containing somatic nerves in the levator ani muscle of women with genitourinary prolapse. Acta Obstet Gynecol Scand, 1999,78:2.

二级参考文献19

  • 1陈娟,郎景和,朱兰,刘珠凤,孙大为,冷金花,任海涛,赵艳环,关宏志.压力性尿失禁及盆底组织膨出患者肛提肌形态学的观察[J].中华妇产科杂志,2004,39(8):519-521. 被引量：38
  • 2朱兰,郎景和,冯瑞娥,陈杰.绝经后压力性尿失禁患者盆底支持结构雌激素受体的研究[J].中华妇产科杂志,2004,39(10):655-657. 被引量：42
  • 3郎景和,朱兰.女性盆底功能障碍的手术治疗评价[J].中国实用妇科与产科杂志,2005,21(4):204-205. 被引量：54
  • 4[1]Maral I,Ozkardes H,Peskircioglu L,et al.Prevalence of stress urinary incontience in both sexes at or after age 15 years:a cross-sectional study.J Urol,2001,165:408-412.
  • 5[2]Samuelsson E,Victor A.Svardsudd K.Determinants of urinary incontinence in a population of young and middle-aged women.Acta Obstet Gynecol Scand,2000,79:208-215.
  • 6[3]Mokrzycki M,Mittal K,Smilen S,et al.Estrogen and progesterone receptors in the uterosacral ligament.Obstet Gyencol,1997,90:402-404.
  • 7[4]Barlow D,Samsioe G,van Geelen H.Prevalence of urinary problems in European countries.Maturitas,1997,27:239-248.
  • 8[5]Perez-Lopez FR,Campo Lopez C,Alos L,Juste G,et al.Estrogen and progesterone receptors in the human vagina during the menstrual cycle,pregnancy and postmenopause.Maturitas,1993,16:139-144.
  • 9[6]Chen GD,Oliver RH,Leung BS,et al.Estrogen receptor alpha and beta expression in the vaginal walls and uterosacral ligaments of premenopausal and postrenopausal women.Fertil Steril,1998,71:1 099-1 102.
  • 10[7]Strathy JH,Coulam CB,Spelsberg TC.Comparison of estrogen receptors in human premenopausal and postmenopausal uteri,indication of biologically inactive receptor in postmenopausal uteri.Am J Obstet Gynecol,1982,142:372-382.

共引文献16

同被引文献8

  • 1陆瑜,郎景和,朱兰.女性压力性尿失禁患者盆底结构的雌激素受体[J].中国医学科学院学报,2007,29(3):402-406. 被引量：11
  • 2Stach LB,Hakala AL,Laippala P,et al.Severe depression determines quality of life in urinary incontinent woman.Neurourol Urodyn,2003,22:563-268.
  • 3Delancey JOL.Pathophysiology of adult urinary incontinence.Gastroenterology,2004,126:S23.
  • 4Lang JH,Zhu L,Chen J,et al.Estrogen levels and estrogen receptors in patients with stress urinary incontinence and pelvic organ prolapse.Int J Gynaecol Obstet,2003,80:35-39.
  • 5Grady D,Brown JS,Vittinghoff E,et al.Postmenopausal hormones and incontinence:the Heart and Estrogen/Progestin Replacement Study.Obstet Gynecol,2001,97:116-120.
  • 6Viktrup L,Lose G.The risk of stress incontinence 5 years after first delivery.Am J Obstet Gynecol,2001,185:82.
  • 7柯豫,曹黎静,张永秀.女性压力性尿失禁与产科因素的关系探讨[J].宁夏医学杂志,2001,23(7):393-394. 被引量：6
  • 8赵正卿,王晓琳,田琼.己烯雌酚对去卵巢小鼠学习记忆能力的改善作用[J].第四军医大学学报,2004,25(2):147-149. 被引量：1

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河北医药
2008年 第8期

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