河北省双相障碍的流行病学调查

EPIDEMIOLOGIC SURVEY ON PATIENTS WITH BIPOLAR DISORDER IN HEBEI

[目的]全面了解河北省18岁以上人口双相障碍的患病情况及其特点。[方法]采用多阶段、分层随机抽样方法抽样,年龄为18岁及其以上人群,总样本24000人。以改编后的一般健康问卷12项(GHQ-12)为本次调查的筛选工具,以DSM-Ⅳ-TR轴Ⅰ障碍定式临床检查(SCID-I/P)病人版为本次调查的诊断工具。[结果]24000例被调查者中,实际完成20716例,诊断为双相障碍的病例64人,时点患病率0.313%,终生患病率0.514%;其中双相Ⅰ型障碍时点患病率为0.125%,终生患病率为0.197%,双相Ⅱ型障碍时点患病率为0.048%,终生患病率为0.130%,其他双障碍时点患病率为0.140%,终生患病率为0.188%;时点患病率中双相Ⅰ型障碍女性高于男性(P﹤0.01),其他双障碍男性高于女性(P﹤0.01);双相Ⅱ型障碍男女之间差异无统计学意义(P﹥0.05);双相Ⅰ型障碍和双相Ⅱ型障碍城乡之间患病率差异无统计学意义(P﹥0.05),其他双障碍农村高于城市,差异有统计学意义(P﹤0.05);各年龄段患病率以30～49岁最高。[结论]通过本次调查,基本掌握了河北省双相障碍的患病情况、流行特点及分布规律,为制订精神卫生相关政策提供了比较全面客观的依据。

[ Objective ] To fully understand the prevalence and characteristics of patients with bipolar disorder above 18 years old. [Methods] A total of 24, 000 people above 18 years were included by multi-stage and stratified random sampling method. The revised Genera/Health Questionnaire （GHQ-12） was carried out to be the screening tool ha this study, the investigation. Structured Clinical Interview for DSM-IV-TR Axis I Disorders-Patient Edition （SCID-I/P） was taken as the diagnosed instrument. [Results] Among 24000 people investigated, 20716 people finished their questionnaires and 64 patients were diagnosed as bipolar disorder with the point prevalence of 0. 313% and lifetime prevalence of 0.514%; The point prevalence and lifetime prevalence for type I bipolar disorder was 0.125% atad 0.197%, respectively, and for type Ⅱ bipolar disorder were 0.048% and 0.130%, respectively, as well as for other type of bipolar disorder were 0.140% and 0.188%, respectively. The point prevalence of type I bipolar disorder for female was significantly higher than that for male （P 〈 0.01）, and the rate of other type of bipolar disorder for male was significantly higher when compared with female （P 〈 0.01 ） ; There were no signifieant difference between the prevalence of type Ⅱ bipolar disorder in male and female （P 〉 0.05）. The prevalence of type I and type Ⅱ bipolar disorder did not showed significant difference between rural and urban people （P 〉 0.05）, and the prevalence of oth- er type of bipolar disorder among rural people was significantly higher when compared with urban people （P 〈 0.05）; The age of people with bipolar disorder were concentrated in 30-49 years old. [ Conclusion ] Through the investigation, we have well understanding of the prevalence, epidemiologic characteristics and distribution regularity of bipolar disorder in Hebei, so as to provide general and objective basis for formulating related policy for mental health.