摘要
[目的]探讨大剂量甲氨蝶呤治疗急性淋巴细胞白血病的有效性和安全性以及碱化对甲氨蝶呤血药浓度的影响。[方法]21例急性淋巴细胞白血病患儿随机分为碱化组(治疗组)与非碱化组(对照组),共60例次接受剂量为MTX4.0g/m2的治疗,检测不同时间段的血药浓度。[结果]在用药后0.5、12、24h两组间血药浓度无统计学差异,但在用药后48、72h碱化明显降低MTX的浓度。对照组不良反应发生率较治疗组多,但无统计学差异。[结论]大剂量甲氨蝶呤治疗儿童急性淋巴细胞白血病是安全、有效的,碱化可以降低第3相甲氨蝶呤的浓度。
[Objective] To detect the efficacy and safety of high dose met hotrexate （HDMTX） chemotherapy in the treatment of children with acute lymphoblastic leukemia and the effect of basification on the concentration of methotrexat. [Methods] 21 children with acute lymphoblastic leukemia who received high dose of HDMTX （4.0 g/m^2） for 60 times were involved in this study, and were randomly divided into basification group （treatment group） and non-basitication group （control group）. The blood concentration of methotrexate was determined at different time. [ Results]The blood concentration of methotrexatc did not showed significant different at the time of 0.5h, 12h and 24h post-treatment between the two groups. The blood concentration of methotrexate at the time of 48h and 72h after treatment are significant lower in treatment group compared with the controls. The incidence of adverse effect in treatment group was higher than that in control group with no significant difference. [ Conclusion] It is effective and safe of HDMTX chemotherapy in the treatment of children with acute lymphoblastic leukemia. Basification could reduce third phase blood concentration of methotrexate.
出处
《现代预防医学》
CAS
北大核心
2008年第16期3220-3221,共2页
Modern Preventive Medicine
关键词
血药浓度监测
甲氨蝶呤
白血病
Blood concentration monitoring
Methotrexate
Acute lymphoblastic leukemia
