联合测定血清总TBA和CRP在肝硬化诊断中的临床意义

CLINICAL SIGNIFICANCE OF SIMULTANEOUS DETERMINATION OF TOTAL TBA IN BLOOD SERUM AND CRP IN THE DIAGNOSIS OF LIVER CIRRHOSIS

[目的]探讨肝硬化患者血清总胆汁酸(TBA)和C反应蛋白(CRP)检测在肝硬化诊断中的临床意义。[方法]采用酶比色法测定硬化患者血清TBA,用快速透射免疫比浊法测定CRP,并对其结果进行分析。[结果]肝硬化患者血清TBA和CRP水平明显高于正常对照组(P﹤0.01),且病情越严重,TBA和CRP含量就越高。[结论]联合检测肝硬化患者血清TBA和CRP含量,既有助于发现肝脏合成及代谢功能的早期损害,又能了解肝内炎症活动及肝细胞变性坏死的情况,为临床诊断和治疗肝硬化提供重要的参考依据。

[Objective] To explore the clinical significance of total bile acid （TBA） and C the response protein （CRP） of patients with liver cirrhosis in detection of liver cirrhosis. [ Methods ] TBA in blood serum was detected by enzyme color method, CRP was measured by the fast transmission immunity turbidimetric method, and their results were analyzed. [ Results] TBA in blood serum and the CRP level of patients with liver cirrhosis was significantly higher than those in normal people （P 〈 0.01 ）. The amount of TBA and CRP increased with the severity of patient＇s condition. [Conclusion] Simultaneous deterruination was performed to detect the content of TBA in serum and CRP, which would be helpful to find the early damage of liver synthesis and metabolism function, and understand the status of inflammation activity of liver and degeneration and necrosis of liver cell so that to provide reference and basis for clinical analysis and treatment of liver cirrhosis.