缺血性脑卒中患者颈动脉粥样硬化与胰岛素抵抗的关系探讨

EXPLORATION OF THE ASSOCIATION BETWEEN CAROTID ATHEROSCLEROSIS AND INSULIN RESISTANCE AMONG PATIENTS WITH CEREBRAL ARTERIAL THROMBOSIS

[目的]探讨缺血性脑卒中患者颈动脉粥样硬化与胰岛素抵抗的关系。[方法]颈内动脉系短暂脑缺血发作患者70例,脑梗塞患者90例,根据糖耐量试验分为胰岛素抵抗组与非胰岛素抵抗组,分别应用超声检测颈动脉粥样硬化情况。[结果]胰岛素抵抗组颈动脉异常率81.2%,非胰岛素抵抗组颈动脉异常率为41.4%,两组间差异有统计学意义(P﹤0.05)。[结论]缺血性脑卒中患者胰岛素抵抗与颈动脉粥样硬化密切相关,表明胰岛素抵抗是缺血性脑卒中的一个重要的危险因素。

[ Objective] To explore the association between carotid atherosclerosis and insulin resistance （IR） among patients with cerebral arterial thrombosis. [Methods] There were 160 patiens with cerebrovascular disease confirmed by cerebral angiography in this study, 70 cases with transient ischemic attack and 90 cases with cerebral infarctin were collected in the study, and the were divided into insulin resistance group and insulin non-resistance group according to the carbohydrate tolerance test, then the situation of atherosclerosis were determined by Doppler ultrasonography. [ Results] The prevalence of carotid abnormality in insulin resistance group was 81.2%, and in insulin non-resistance group was 41.4% （P 〈 0.05）. There are significant difference between （P 〈 0.05 ）. [ Conclusion ] Carotid atherosclerosis of patients with cerebral arterial thrombosis had close association with insulin resistance, which indicates that the insulin resistance was an important risk factor for cerebral arterial thrombosis.