网织血小板参数对儿童特发性血小板减少性紫癜的临床价值

THE CLINICAL VALUE OF RETICULATED PLATELETS COUNTS IN CHILDHOOD WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

[目的]探讨网织血小板(RP)的百分率和绝对值对儿童特发性血小板减少性紫癜(ITP)中的临床意义。[方法]采用流式细胞术测定30例ITP患儿外周血中RP的百分率和绝对值,并与15例对照组进行比较。[结果]对照组的RP%为(10.71±3.69)%,绝对值为17.82±9.31,而病例组的RP%为(28.31±7.46)%,明显高于对照组(P﹤0.05),而绝对值为16.39±5.18,低于对照组。[结论]RP的百分率及绝对值可作为判断血小板生成动力学的指标,也可作为血小板减少症鉴别诊断的有用指标,在临床上判断ITP具有重要意义。

[Objective] To explore the clinical value of the percentage and absolute count of reticulated platelets （RP） in childhood with idiopathic thrombocytopenic purpura （ITP）. [Methods] 30 children with ITP and 15 cases as controls were collected, whose percentage and absolute count of RP from peripheral blood were determined by flow cytometry. [ Results] RP% and absolute count of RP in controls were （10.71±3.69） % and 17.82±9.31, respectively, while in cases, the RP% was （28.31±7.46） % which was significantly higher than that of controls （P 〈 0.05）, and absolute count of RP was 16.39±5.18, lower than that of controls. [ Conclusion] The percentage and absolute count of RP could be regarded as the useful target for determining the generation of dynamics of platelets and for differential diagnosis of thrombopenia, which have important significance in determining ITP.