肾移植术后环孢素血药浓度与患者体内因素相关性分析

Relevance of Blood Concentration of Cyclosporine A to In Vivo Factors of Patients After Undergoing Renal Transplantation

目的:研究肾移植术后环孢素(CsA)血药浓度与患者体内因素的相关性。方法:采用回顾性调查方法,查阅我院肾移植术后1周～1个月内服用CsA的患者病历,记录CsA血药浓度及相应的生化检验值,并应用SPSS13.0统计软件对数据进行全回归分析和多元线性回归分析。结果:全回归分析表明,在丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)、AST/ALT、总蛋白(TP)、白蛋白(ALB)、直接胆红素(DBIL)、间接胆红素(IBIL)、胆碱酯酶(CHE)、总胆汁酸(TBA)、乳酸脱氢酶(LDH)、尿素(Urea)、尿酸(UA)、肌酐(Crea)等生化因素协同存在的情况下,上述各值与CsA单位剂量血药浓度存在线性关系(P<0.05);进一步用多元线性回归分析表明,CsA单位剂量血药浓度与TP之间存在线性关系(P<0.05)。结论:患者TP是影响CsA血药浓度的独立因素。而ALT、AST、AST/ALT、ALB、DBIL、IBIL、CHE、TBA、LDH、Urea、UA、Crea等可能与TP协同作用而影响CsA血药浓度。

OBJECTIVE： To study the relevance between blood concentration of cyclosporine A （CsA） and the in vivo factors of patients after undergoing renal transplantation. METHODS： Patients receiving oral CsA administration within 1wk-1mo after undergoing kidney transplantation in our hospital were reviewed retrospectively and the blood concentration of CsA and the corresponding biochemical testing values were recorded and analyzed with regression analysis and multiple linear regression analysis using SPSS 13.0 software. RESULTS： According to regression analysis, the linear statistical significance existed between the blood concentration of unit dose CsA and the corresponding biochemical values including ALT, AST, AST/ ALT, TP, ALB, DBIL, IBIL, CHE, TBA, LDH, Urea, UA and Crea（P〈0.05）; And according to multiple linear regression analysis, the linear statistical significance existed between the blood concentration of unit dose CsA and the total protein （TP） （P 〈0.05）. CONCLUSION： TP is the independent factor influencing the blood concentration of CsA. And the influence of the corresponding biochemical values such as ALT, AST, AST/ALT, ALB, DBIL, IBIL, CHE, TBA, LDH, Urea, UA, Crea on the blood concentration of CsA is possibly related to their joint action with TP.