阿昔洛韦致不良反应60例文献分析

Adverse Drug Reactions Induced by Acyclovir:Literature Review of 60 Cases

目的:探讨阿昔洛韦致药品不良反应(ADR)的一般规律及特点。方法:查阅《中国医院知识仓库(CHKD)全文期刊库》1994～2006年阿昔洛韦致ADR的有关文献52篇(共60例),进行统计、分析。结果:阿昔洛韦致ADR在31～60a发生率较高,多发生于用药后10～60min内(41.67%),临床表现复杂多样,涉及机体多个器官或系统,主要和严重的ADR为肾功能损害。结论:临床医师、药师应重视阿昔洛韦所致ADR,坚持合理用药。

OBJECTIVE： To explore the general patterns and characteristics of the adverse drug reactions （ADR） induced by acyclovir. METHODS： 52 acyclovir-induced ADR reports （60 cases） published in China Hospital Knowledge Database from 1994 to 2006 was analyzed statistically. RESULTS： The ADR induced by acyclovir were more often occurred in patiems aged from 31 to 60, with 41.67% appearing within 10--60 min after drug use. The clinical presentation was complex and diverse, which involved different systems and organs, predominantly the lesion of renal function. CONCLUSION： Clinician and pharmacists should attach great importance to Acyclovir- induced ADR in clinical practice and stick to rational drug use.