酚妥拉明佐治毛细支气管炎的临床观察

Clinical observation of minipump for phentolamine injection in the treatment of bronchiolitis

目的:观察酚妥拉明微量泵静脉注射辅佐治疗毛细支气管炎的临床疗效。方法:将80例诊断为毛细支气管炎的患儿随机分为试验组和对照组各40例,对照组给予常规治疗,试验组在对照组基础上加酚妥拉明持续静脉注射,24h微量泵维持,速度为2μg/(kg.min),连用5d。结果:试验组总有效率95.0%,对照组总有效率80.0%,两组比较,u=2.09,P<0.05,差异具有统计学意义;试验组的喘憋消失时间为(1.74±0.45)d、哮鸣音消失时间为(4.46±1.34)d、咳嗽缓解时间为(5.84±1.90)d及住院时间(7.56±2.08)d,均短于对照组(P均<0.05),差异有统计学意义(P均<0.05)。结论:微量泵维持静脉注射酚妥拉明辅佐治疗毛细支气管炎临床疗效显著,不良反应少。

Objective： To explore the clinical effect of minipump for phentolamine injection in the treatment of bronchiolitis. Methods： 80 cases of bronehiolitis were separated randomly into the experiment group and the control group （40 eases for each）. Both groups received the same routine treament, but the experiment group received continually phentolamine injection by minipump for 5 days in addition. The injection speed was controlled to 2 μg/（ kg ·min）. Results： The total effective rate of experiment group was 95%, which was higher than that of the control group （80%）. The difference was statistically significant （u = 2. 09 ,,P 〈 0.05 ）. The experiment group costed shorter time for the release of asthma （ 1.74 ± 0.45 days）, wheeze （4.46 ± 1.34 days） and cough （5.84 ± 1.90 days）, and took fewer days in hospital （7.56 ± 2.08 days） than the control group （P 〈 0.05 ）. Conclusions ： The minipump for continual phentolamine injection in the treatment of bronehiolitis has obvious effect, which is safe and has few side effects.