支气管哮喘患者血清脑源性神经营养因子含量的变化及其临床意义

Changes of brain deriveded neurotrophic factor(BDNF) and its clinical significance in asthma

目的探讨脑源性神经营养因子(BDNF)在哮喘发病中的作用及其与肺功能的关系。方法采用酶联免疫吸附法(ELISA)测定30例支气管哮喘患者急性发作期、缓解期及30例健康对照者血清中BDNF的含量,同时检测肺功能。结果支气管哮喘患者急性发作期血清中BDNF含量(6.41±2.45ng/ml)较正常对照组(1.34±0.28ng/ml)明显升高,差异显著(P均<0.01)。缓解期血清BDNF(3.77±1.24ng/ml)含量较急性发作期明显下降,肺功能改善,差异显著(P均<0.01),但仍高于正常对照组。哮喘患者血清BDNF含量与PEF、FEV1成显著负相关(r=-0.472,P<0.001;r=-0.494,P<0.001)。结论哮喘患者急性发作期BDNF水平升高,其水平与肺功能成负相关,BDNF在哮喘的发病中起着一定的作用。

Objective To explore the significance of BDNF in asthma and to analyze the relationship between BDNF and pulmonary function.Methods Serum levels of BDNF were measured in 30 patients with acute asthma and stable asthma compared with 30 healthy donors by ELLISA method.Meanwhile the pulmonary functions of all participants were measured.Results The level of serum BDNF significantly increased in patients in the acute asthma group （6.41±2.45 ng/ml） as compared with the healthy donors group（1.34±0.28 ng/ml （P〈0.01）.The level of serum BDNF significantly decreased in patients with the stable asthma group（3.77±1.24 ng/ml）as compared with the acute asthma.There was markedly statistical significance between the stable asthma group and the healthy donors group （P〈0.01）.The level of BDNF in the patients with asthma were negatively correlated with PEF,FEV1（r=-0.472,P〈0.001;r=-0.494,P〈0.001 respectively）.Conclusion These results suggest that there is a high level expression of BDNF in the patients with acute asthma.The level is negatively correlated with its pulmonary function;BDNF has a potent effect on pathogenesis of asthma.