氟西汀治疗帕金森病伴抑郁的疗效观察

The Clinic Observation to Fluoxetine though Treating Parkinson's with Depression

目的:探讨氟西汀治疗帕金森病伴抑郁的临床疗效。方法:将43例帕金森病伴抑郁的患者随机分为氟西汀治疗组23例和对照组20例,基础治疗相同,氟西汀治疗组加用氟西汀20mg/d治疗,于治疗前及治疗8周后采用帕金森病统一评分量表(UPDRS)评定病情严重程度。汉密尔顿抑郁量表(HAMD)17项版本评定抑郁严重程度。结果:氟西汀治疗组在治疗8周后UPDRS及HAMD评分明显减少,抗抑郁疗效总有效率明显高于常规药物治疗组。结论:氟西汀治疗PD伴抑郁患者,不但能有效改善抑郁状态,同时也有利于改善运动障碍,对患者生活质量的改善有积极作用。

Objective： To explore the clinical effect of fluoxetine in the patients with Parkinson＇s disease （PD）and depression. Methods：43 cases of PD with depression were randomly divided into therapy group （23 cases） and control group （20cases）, On the same basic treatment, the therapy group was treated with fluoxetine（20 mg/d） additionally. Disease severity was evaluated by the unified Parkinson＇ s disease rating scale （UPDRS） and the level of depression was evaluated by 17-item Hamilton-Depression Rating Scale （HAMD-17） before and after 8 weeks treatment. Results：At the end of 8th week, the scores of UPDRS and HAMD in the therapy group were significantly reduced, and the total effective antidepressant efficacy was significantly higher than that of control group. Conclusion. Fluoxetine in the treatment of PD patients with depression, can not only effectively improve the depressive state, but restore movement disorders obviously. Fluoxetine plays a positive role in improving ＂the patient＂s life quality.