带状疱疹后遗神经痛患者T淋巴细胞亚群的临床意义

Clinical Significance of T-lymphocyte Subsets in Post Herpetic Neuralgia

目的研究T淋巴细胞亚群与带状疱疹后遗神经痛发病的关系。方法应用流式细胞仪技术,通过免疫荧光法测定,不同治疗方案的两组患者治疗前后外周血T淋巴细胞亚群值与对照组比较。结果52例带状疱疹患者经胸腺肽α1治疗后CD3、CD4、CD4/CD8明显高于治疗前,且带状疱疹后遗神经痛发病率显著降低;52例经泛昔洛韦治疗后的CD3、CD4、CD4/CD8与治疗前无明显差异;24例带状疱疹后遗神经痛患者CD3、CD4、CD4/CD8均明显低于对照组。结论带状疱疹后遗神经痛患者T淋巴细胞亚群免疫功能低下,加用胸腺肽α1治疗能调节T淋巴细胞亚群功能,对预防带状疱疹后遗神经痛具有良好效果。

Objective To study the role of T-lymphocyte subsets in the pathogenesis of post herpetic neuralgia （PHN）. Methods Totally 104 patients of herpes zoster （HZ） were included, and divided into receive thymosin α1 therapy or famciclovir therapy. Forty-two healthy subjects served as normal controls. T-lymphocyte subsets were measured by immunofluorescence technique and flow cytometry （FCM）. Results After thymosin al therapy, CD3, CD4, CD4/CD8 in 52 HZ patients were significantly higher than that before and the overall incidence of PHN was significantly lower. However, the T-lymphocyte subsets levels in famciclovir therapy group were not significantly changed. In 24 PHN patients of the two treatment groups, significantly decreased CD3, CD4, CD4/CD8 were found as compared with that in normal controls. Conclusion T-lymphocytes immunocompromised in PHN patients and thymosin α1 for HZ patients could achieve better outcomes.