超抗原靶向抗肿瘤研究进展

Advancement on targeted therapy of malignancies with superantigens

超抗原作为一种强大的T细胞激活剂，单用极低浓度便可激活大量的T淋巴细胞克隆来杀伤肿瘤细胞，但这种杀伤作用缺乏特异性。对此，通过单抗导向或将超抗原结合于肿瘤细胞表面以及基因工程等手段，国内外的学者已在超抗原的靶向抗肿瘤治疗方面开展了大量工作。

Superantigens are potent activators of T cells, causing rapid and massive proliferation of T cells and superantigen -dependent-cell-mediated cytotoxicity with extremely low doses. However such antitumor effects lack selectivity. Thus with the methods including monoclonal antibody targeting or binding superantigens to the surface of tumor cells as well as genetic engineering, scientists have done lots of work on targeted therapy of malignancies with superantigen.