P-糖蛋白与CD44在肿瘤中表达的相关性

Correlation between P- glycoprotein and CD44 in cancer

P-糖蛋白（P—gp）是最重要的肿瘤多药耐药蛋白之一；CD44分子异常表达与肿瘤的侵袭和转移密切相关。近年来的研究发现，P-gp和CD44分子在肿瘤中的表达具有某种相关性，即肿瘤多药耐药与侵袭转移之间可能存在着某种关联。探讨两者可能存在的相关性及深入了解两者之间的内在联系，对肿瘤治疗具有重要的指导意义。

P-glycoprotein （P-gp） and CD44 have been characterized and are known to be determinants of muhidrug resistance （MDR） and cancer metastases. Recent researches suggest that there is a correlation belween P-glycoprotein （MDR） and CD44 （invasion and metastases）. A better understanding of any relationship between drug resistance and tumor metastasis may lead to more effective tumor treatment.