TNF—α启动子区域基因多态性与肺癌易感性

Relationship between TNF-α polymorphisms in its promotor region and susceptibility of lung cancer

肺癌的遗传易感性机制在肺癌发病中起重要作用。研究发现肿瘤坏死因子-α（TNF-α）在肺癌患者中明显升高。其增高的原因可能是由于TNF-α启动子区域基因多态性影响了其转录和表达。TNF-α基因多态性可以作为肺癌易感性的遗传标志。

Genetic susceptibility of lung cancer plays an important role in genesis of lung cancer. Studies find that tumor necrosis factor α（TNF-α） is significantly up-regulated in lung cancer patients. It ,nay be correlated with the TNF-α polymorphism in its promoter region which affects its transcription and expression. TNF-α polymorphisms ,nay be an important genetic marker for susceptibility of lung cancer.