期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

非小细胞肺癌微转移及其检测

Micrometastasis of non- small cell lung cancer and its detection
原文传递
导出
摘要 检测非小细胞肺癌（NSCLC）微转移可以更准确地进行分期、指导治疗、判断预后。目前NSCLC微转移标志物的研究主要集中在细胞角蛋白（CK）19、人类肺组织特异性基因（LUNX）、癌胚抗原（CEA）mRNA、癌基因和抑癌基因等。NSCLC微转移部位的研究以淋巴结和骨髓多见，胸膜腔报道较少，外周血的报道逐渐增多。 Micrometastasis of carcinoma is one of the most significant pieces of evidence for molecular staging. Detection of micromctastasis of non-small-cell lung cancer plays a significant role in staging precisely, guiding treatment and predicting the prognosis of patients. This review is focused on the latest developments of markers such as CK19, LUNX, CEA mRNA, oncogcnc and anti-oncogcnc. The sites about micromctastasis of non-small-cell lung cancer arc usually reported in lymph node and bone marrow, rarely in pleural cavity and increasingly in peripheral blood.
作者 耿佃忠(综述) 茅国新(审校)
机构地区 南通大学附属医院化疗科
出处 《国际肿瘤学杂志》 CAS 2008年第7期507-509,共3页 Journal of International Oncology
关键词 肿瘤转移 癌 非小细胞肺 Neoplasm, metastasis Carcinoma, non- small- cell lung
分类号 R734-2 [医药卫生—肿瘤]
  • 相关文献

参考文献14

  • 1Satoh Y Hoshi R, Ishikawa Y, et al. Recurrence patterns in patients with early stage non-small cell lung cancers undergoing positive pleural lavage cytology. Ann Thorac Surg,2007,83( 1 ) :197-202.
  • 2LinksLim E, Ali A, Theodorou P, et al. Intraoperative pleural lavage cytology is an independent prognostic indicator for staging non-small cell lung cancer. J Thorac Cardiovasc Surg, 2004 , 127 (4) :1113- 1118.
  • 3Sienel W, Mecklenburg I, Dango S, et al. Detection of MAGE-A transcripts in bone marrow is an independent prognostic factor in operable non-small-cell lung cancer. Clin Cancer Res, 2007, 13 ( 13 ) : 3840-3847.
  • 4Hirata H, Hisatomi H, Kawakita M, et al. Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin Ⅱ derived primers in polymerase chain reaction. Oncol Rep, 2003, 10(4) :963-966.
  • 5Ge M, Shi D, Wu Q, et al. Fluctuation of circulating tumor cells in patients with lung cancer by real-time fluorescent quantitative-PCR approach before and after radiotherapy. J Cancer Res Ther, 2005,1 (4) :221-226.
  • 6Hayes DF, Cristofanilli M, Budd GT, et al. Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin Cancer Res,2006,12( 14 Pt 1 ) :4218-4224.
  • 7Riethdorf S, Fritsche H, Mailer V, et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the cell search system. Clin Cancer Res,2007,13 (3) :920-928.
  • 8Yamashita J,Matsuo A, Kurusu Y, et al. Preoperative evidence of circulating tumor cells by means of reverse transcriptase-polymerase chain reaction for carcinoembryonic antigen messenger RNA is an independent predictor of survival in non-small cell lung cancer: a prospective study. J Thorac Cardiovasc Surg,2002,124 (2) :299-305.
  • 9陈廷锋,蒋国梁,张宜勤,王丽娟,傅小龙,钱浩,吴开良,赵森.非小细胞肺癌根治性化放疗前后外周血微转移的检测及其预后[J].中华肿瘤杂志,2007,29(5):365-368. 被引量：4
  • 10Osaki T, Oyama T, Gu CD, et al. Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage Ⅰ non-small-cell lung cancer. J Clin Oncol, 2002,20( 13 ) :2930-2936.

二级参考文献22

  • 1蒋治勤,蒋国梁,施达仁,张容轩,傅小龙,钱浩.Ⅰ期非小细胞肺癌预后因素的研究[J].中华肿瘤杂志,2004,26(6):364-368. 被引量：6
  • 2Berhardt WE, Albain KS, Pass H, et al. Induction treatment before surgery for non-small cell lung cancer [J]. Lung Cancer, 2003,42 ( Suppl 1 ): S9-14.
  • 3Kwiatkowski DJ, Harpole DH, Godleski J. Molecular pathologic substaging in 244 stage Ⅰ non-small cell lung cancer patients: clinical implications [J]. J Clin Oncol, 1998,16(7): 2468-2477.
  • 4Broermann P, Junker K, Brandt BH, et al. Trimodality treatment in stage Ⅲ non-small cell lung carcinoma:prognostic impact of K-ras mutations after neoadjuvant therapy[J]. Cancer, 2002,94(7):2055-2062.
  • 5Ylisirnio S, Hoyhtya M, Turpeenniemi-Hujanen T. Serum matrix metalloproteinases -2, -9 and tissue inhibitors of metalloproteinases -1, -2 in lung cancer-TIMP-1 as a prognostic marker [J]. Anticancer Res, 2000,20(2B): 1311-1316.
  • 6Masuya D, Huang C, Liu D, et al. The intratumoral expression of vascular endothelial growth factor and interleukin-8 associated with angiogenesis in non-small cell lung carcinoma patients [J]. Cancer, 2001,92(10): 2628-2638.
  • 7Junker K, Langner K, Kliker F, et al. Grading of tumor regression in non-small cell lung cancer [J]. Chest, 2001,120(5): 1584-1591.
  • 8Betticher DC, Hsu Schmitz SF, Totsch M, et al. Mediastinal lymph node clearance after docetaxel-cisplatin neoadjuvant chemotherapy is prognostic of survival in patients with stageⅢA pN2 non-small-cell lung cancer: a multicenter phase Ⅱtrial [J]. Clin Oncol, 2003,121(9): 1752-1759.
  • 9Mattson KV, Abratt RP, ten Velde G. Docetaxel as neoadjuvant therapy for radically treatable stage Ⅲ non-smallcell lung cancer: a multinational randomised phase Ⅲ study[J]. Ann Oncol, 2003,14( 1 ): 116-122.
  • 10Rosell R, Gomez-Codina J, Camps C, et al. Preresectional chemotherapy in stage ⅢA non-small cell lung cancer: a 7-year assessment of a randomized control trial [J]. Lung Cancer, 1999,26 ( 1 ): 7-14.

共引文献3

国际肿瘤学杂志
2008年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部