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p53基因治疗在恶性淋巴瘤治疗中的应用

Application of p53 gene therapy for malignant lymphoma
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摘要 多数恶性淋巴瘤患者有突变的p53基因过表达，并且实验表明p53基因与恶性淋巴瘤的发生发展有密切关系。因此，以重组腺病毒为载体将正常p53基因导人肿瘤细胞中并使其稳定表达将会对恶性淋巴瘤起到治疗作用。这已经在基础研究中得到了证实。 In majority of malignant lymphoma patients the overexpression of mutant p53 gene can be found, and experiments show that p53 gene and the genesis currence and development of malignant lymphoma are closely related. Thus, normal p53 gene carried by recombinant adenovirus vector into tumor cells and its stable expression will play a theraputic role in the treatment of malignant lymphoma. This has been confirmed by the basic research.
作者 李栋庆(综述) 范我(审校)
机构地区 苏州大学放射医学与公共卫生学院基础核医学教研室
出处 《国际肿瘤学杂志》 CAS 2008年第7期547-549,共3页 Journal of International Oncology
基金 国家自然科学基金资助项目（30471974）
关键词 基因法 淋巴瘤 基因 p53 Gene therapy Lymphoma Genes, p53
分类号 R730.59 [医药卫生—肿瘤]
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参考文献11

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国际肿瘤学杂志
2008年 第7期

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