Survivin和VEGF-C联合检测在评估高发区食管鳞癌预后中的作用

Role of combinative detection of the expression of survivin and VEGF-C in assessing prognosis of esophageal squamous cell carcinoma in high-incidence area

目的研究Survivin和VEGF-C联合检测在评估高发区食管鳞癌预后中的作用。方法采用免疫组化方法检测Survivin和VEGF-C蛋白在食管鳞癌组织中的表达情况。83例食管鳞癌患者均为林州市居民,随访在5年以上,术前未接受放疗及化疗。结果Survivin阳性表达组和VEGF-C阳性表达组患者的5年生存率均明显低于阴性表达组(P<0.05)。根据Survivin和VEGF-C表达情况,探索性建立的分子水平多因素分级模型显示:0,1和2三个级别组患者的5年生存率有明显差别(χ2=32.20,P<0.001)。结论联合检测Survivin和VEGF-C表达可以提供较准确的预后信息,可能有助于临床评估患者预后和制定个体化的治疗方案。

Objective To study the role of combinative detection of the expression of survivin and VEGF-C in assessing prognosis of esophageal squamous cell carcinoma in high-incidence area. Methods Immunohistocbemistry was applied to detect the expression of survivin and VEGF-C in esophageal squamous cell carcinoma（ESCC） tissues from 83 patients. All patients were local residents of Linzhou city, and were regularly followed up more than 5 years after surgery until January 2005. All the patients had not received radiation therapy or chemotherapy before surgery. Results The 5-year overall survival rate of survivin positive group and VEGF-C positive group was statistically lower than that of negative groups respectively （P 〈 0. 05）. The multiple-factor-grade （MFG） model built on the basis of survivin and VEGF-C expression showed that the 5-year overall survival rate was significantly different among MFG-O group, MFG-1 group and MFG-2 group（ Х^2 = 32. 20, P 〈 0. 001 ）. Conclusion Combinative detection of the expression of survivin and VEGF-C may provide relatively accurate information in predicting the prognosis of ESCC. It might be helpful in evaluating ESCC patient prognosis and individualizing clinical therapeutic strategies.