摘要
目的:建立了全面测定手术粘弹剂中残留溶剂的方法。方法:采用气相色谱-质谱联用仪对手术粘弹剂中残留溶剂进行定性分析,优化了溶剂切除时间、质荷比扫描范围等实验条件,并用气相色谱外标法对其中主要的残留物甲醇进行了定量分析。结果:用该法测定出了某手术粘弹剂中的数种残留溶剂,包括甲醇、异丙醇、乙苯、对二甲苯、邻二甲苯,其中甲醇的残留量为312μg·g^(-1)。结论:本方法灵敏度高,重复性好,简便可行,可用于手术粘弹剂的质量控制。
Objective：A method was established for qualitative and quantitative determination of remnant solvents in surgical viscoelastic agents. Method：GC - MS was used to qualify remnant solvents in surgical viscoelastic agents. Test conditions, such as solvent delay - time, m/z scan range, were optimized. Methanol, the dominating remnant solvents, was quantified by GC external standard. Results：Several remnant solvents in surgical viscoelastic agents were determined,including methanol, ethanol, ethyl benzene, p - xylene and o - xylene. The amount of remnant methanol is 312 μg· g ^-1. Conclusion：The method is sensitive, simple and good stability,which can be used for the quality control of surgical viscoelastic agents.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2008年第7期1196-1198,共3页
Chinese Journal of Pharmaceutical Analysis
关键词
粘弹剂
残留溶剂
测定方法
GC—MS
viscoelastic agent
remnant solvents
determination methods
GC - MS
