GAS、SS在重型颅脑损伤合并急性胃粘膜病变中的动态变化

Dynamic changes of gastrin and somatostatin in severe craniocerebral injury combined with acute gastric mucosa lesion

目的观察重度颅脑损伤合并急性胃粘膜病变(AGML)患者血液中胃泌素(GAS)、牛长抑素(SS)水平的动态变化,并探讨其机制与意义。方法采用放射免疫法检测45例重度颅脑损伤患者伤后第1 d及第3、7、10 d血清GAS及血浆SS的水平,同时观察AGML病变情况。结果重度颅脑损伤后血清GAS水平高于正常对照组;血浆SS水平低于正常对照组,并发现AGML患者血清GAS水平高于无AGML患者;血浆SS水平低于无AGML患者。结论GAS和SS均参与了重度颅脑损伤合并AGML的发生和发展,对GAS、SS的动态检测可作为重度颅脑损伤并AGML的预测指标。

Objective To evaluate the levels of gastrin （GAS） and somatostatin （SS） dynamically in the blood of severe craniocerebral injury combined with acute gastric mucosal lesion （AGML）. Methods The levels of GAS in serum and SS in plasma of 45 patients were detected by radioimmnoassay （RIA） at 1 d, $ d, 7 d, 10 d after severe injury, meanwhile the pathological changes of AGML were observed. Results The level of GAS was higher in the severe craniocerebral injury group than that in the control group, while the level of SS was lower in the severe craniocerebral injury group than that in the control group. The level of GAS in the patients combined with AGML was higher than that of the patients without AGML, while the level of SS was lower than that of the patients without AGML. Conclusion The development of severe craniocerebral injury combined with acute gastric mucosal lesion correlated with GAS and SS. To detect the level of GAS and SS dynamically may become a predictive index of severe craniocerebral injury combined with acute gastric mucosal lesion.