P53-MDM2负反馈在幽门螺杆菌致病中的作用

Role of P53-MDM2 negative-feedback in the pathopoiesis of Helicobacter pylori

鼠双微体-2基因(Murine double minute-2,mdm2)是P53的下游调节基因之一,P53启动mdm2转录,MDM2反过来又抑制P53活性,二者形成一个负反馈环,以保持正常情况下P53处于低水平状态.该负反馈受多种因素调节,在肿瘤发生、发展中有重要作用.目前幽门螺杆菌(Hpylori)被认为是许多胃肠疾病致病的关键因素,其致病、致癌机制也成为近年研究的热点,其中大量的研究探讨了p53基因网络在Hpylori致病中的作用.而P53-MDM2负反馈调控机制可能在Hpylori致病、致癌过程中发挥重要作用.

Murine double minute-2 （mdm2）, one of downstream genes of P53, forms a negative feedback loop with P53 to maintain P53 at a low level under normal circumstances. On one hand, P53 activates transcription of mdm2. On the other hand, MDM2 suppresses activity of P53. The negative feedback, which plays an important role in tumor development, is regulated by a variety of factors. At present, Helicobacter pylori （H pylori） is considered as a key gastrointestinal disease pathogenic factor. Its pathogenic or carcinogenic mechanism has become a hot research issue in recent years, and there have been substantial research on the role of p53 gene networks in H pylori pathogenic process. And the P53-MDM2 negative feedback may play an important role in this process.