相转移催化下的水相Heck反应研究

Study of Aqueous Heck Reaction Catalyzed by Phase Transfer Agents

Heck反应是一类重要的构建碳—碳键的有机反应,通过添加相转移催化剂实现了水相中的Heck反应,而且不需要添加膦配体,并对反应中相转移催化剂和碱的选择及用量等条件进行了优化,碘苯和溴苯分别与丙烯酸甲酯反应的产率最高可达95%和83%。改变其他不同的烯烃,也都能获得较好的结果。

Heck reaction is one of the most important organic reactions. In this paper,Aqueous Heck reaction of iodobenzene and bromobenzene under the catalysis of phase transfer agents were developed, giving the corresponding products in moderate to high yields.