超声波合成2,2,4-三甲基-2,3-二氢-1H-1,5-苯并二嗪

Synthesis of 2,2,4-trimethyl-2,3-dihydro-1H-1,5-benzodiazepine under ultrasound irradiation

在超声波辐射下,以邻苯二胺和丙酮为原料,合成了对2,2,4-三甲基-2,3-二氢-1H-1,5-苯并二嗪.产物经过熔点测试,并进行IR和1HNMR表征确认.工艺参数n(丙酮)∶n(邻苯二胺)为2.2∶1.0,超声波功率为500W,超声波辐射时间为20min时,产率达79.9%.

2,2,4-trimethy1-2,3-dihydro-1H-1 ,5-benzodiazepine was synthesized from o-phenylenediamine and acetone by using ultrasonic method, and was characterized with melting point determination, IR and 1^HNMR methods. When the molar ratio of acetone to o-phenylenediamine was 2.2, and the ultrasonic power was 500 W, the yield reached 79.9% after the reaction was preceded for 20 rain.