基质溶解素-1基因启动子多态性与急性心肌梗死的相关性

Correlative research between polymorphisms of stromeIysin-1 promoter 1612 5A/6A and acute myocardiaI infarction

目的:研究中国南方人群基质溶解素-1基因启动子16125A/6A多态性与急性心肌梗死的相关性。方法:采用DNA测序法检测116例急性心肌梗死患者和105例对照的基质溶解素-1基因启动子序列。结果:①基质溶解素-1基因启动子16125A/6A多态性的三种基因型(5A/5A、5A/6A、6A/6A)符合Hardy-Weinberg分布。②与对照组相比,心梗组的基质溶解素-1基因5A/5A和5A/6A基因型较多见,差异有显著性,P<0.01。③基因型的相对风险分析发现,5A/5A或5A/6A基因型携带者患急性心肌梗死风险是6A/6A基因型的3.050倍(95%可信区间:1.653-5.627)。结论:基质溶解素-1基因启动子16125A/6A多态性可能与中国南方急性心肌梗死的遗传易感性相关联,5A等位基因是急性心肌梗死发病的一个独立危险因素。

Objective： To investigate the relationship between the polymorphism of 1 612 5A/6A in the promoter of the stromelysin-1 gene and the acute myocardial infarction （AMI） in population of southern Chinese. Methods： Using DNA sequencing, the polymorphism of the stromelysin-1 gene was detected in both 116 AMI patients and 105 control subjects. Results： （1） The allelic distribution of the stromelysin-1 gene in both groups matched the Hardy-Weinberg equilibrium （P〉0.05）.（2） The number of 5A allele of the promoter of the stromelysin-1 gene in patients with AMI was higher than that of the control group （P〈0.01）.（3） The odds ratio of the 5A/6A＋SA/SA was 3.050（95% CI, 1.653 to 5.627）. Conclusion： The 1612 5A/6A polymorphism in the promoter of the stromelysin-1 gene is associated with AMI in southern Chinese. The 1612 5A allele in the promoter of the stromelysin-1 gene may play an important role in the pathogenesis of AMI.