恶性肿瘤患者的胰岛素抵抗状态

Status of insulin resistant in patients with malignant tumor

目的:观察恶性肿瘤患者的胰岛素抵抗状态,为肿瘤防治提供指导。方法:测定82例恶性肿瘤患者和82例健康对照者的空腹胰岛素水平,并用稳态模式评估法(HOMA)计算胰岛素抵抗指数。结果:恶性肿瘤组空腹胰岛素水平和胰岛素抵抗指数均高于正常组(P<0.05和P<0.01),但两指标与肿瘤分期、部位、有无肝脏肿瘤(原发或转移)均无关。结论:恶性肿瘤存在胰岛素抵抗现象,其存在仅与肿瘤本身有关。

Objective： To study the role of insulin resistant in patients with malignant tumor.Methods： The levels of fasting insulin （FINS） were detected in both the control group （n=82）and the patients with malignant tumor （n=82）,and the HOMA mode was adopted to calculate the insulin resistant index （IRI）. Results： The level of the fasting insulin and IRI in patients with malignant tumor was higher significantly than that of the controls （P〈0.05 and 0.01 respectively）. They had no correlation with tumor＇ s TNM stage, location, primary or metastatic liver tumor （P〉0.05）. Conclusion： The patients with malignant tumor exist the IR, and IR is only related to tumor.