女性类风湿性关节炎患者血清瘦素水平及相关因子的检测

Detection of leptin level and its related factors in women with RA

目的:探讨瘦素在女性类风湿性关节炎(RA)患者中的表达情况及其与α1-酸性糖蛋白(AAG)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)等指标的关系。方法:用放射免疫分析(RIA)法分别检测63例女性RA患者及30例正常对照者血清瘦素的水平,并与AAG、TNF-α、CRP等作相关分析。同时按有无活动、有无治疗及病程(分≤5年和>5年)等分组分析。结果:63例女性RA患者瘦素含量为(13.18±2.29)μg/L,明显高于正常对照组的(6.92±1.91)μg/L(P<0.01)。血清瘦素水平与AAG存在相关性(P<0.05),而与其他指标无相关性。瘦素水平在活动组和非活动组中差异无显著性(P>0.05)。患者按接受治疗情况分治疗前、未使用强的松、加用强的松三组比较瘦素水平,结果差异无显著性(P>0.05)。病程≤5年组瘦素含量为(17.38±2.29)μg/L,明显高于病程>5年组的(9.55±2.09)μg/L(P<0.05)。结论:女性RA血清瘦素水平升高,与AAG存在相关性,但与病情活动等其他因素无关,推测瘦素可能是一个独立的炎症细胞因子,在RA的炎症反应中发挥一定的作用。

Objective： To explore the expression of leptin in women with RA and its relation with other indexes such as AAG, TNF-α, CRF, etc. Methods： The concentration of leptin in 63 women with RAand 30 healthy controls was detected with RIA. The correlation was analyzed between leptin and TNF- α, CRF and ESR, etc. The patients were divided into several groups and each group was analysed. Results： The serum leptin in 63 women with RA was significantly higher than that of the controls [（13.18 ±2.29） μg/L versus （6.92 ±1.91） μg/L, P〈0.01]. There was correlation between serum leptin and AAG （P〈0.05）. But it did not occurr between other indexes （P〉0.05）. There was no difference between active group and inactive group. There was also no difference among three groups which were divided according to the means of therapy： before therapy, without taken glucocorticoids and after taken glucocorticoids （P〉0.05）. While the leptin in 〉5 year group was higher than that of 〈 5 year group [（17.38 ±2.29） μg/L versus （9.55 ±2.09） μg/L, P〈0.05]. Conclusion： The serum leptin in women with RA is higher than that in the normal one. There is correlation between leptin and AAG. But it isn＇t influenced by other factors,such as the activity of disease. Maybe leptin participates in the inflammation of RA as an independent factor.