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四种疗法根除幽门螺杆菌感染的疗效分析

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摘要 目的:探讨以质子泵抑制剂(奥美拉唑)为基础,4种不同抗生素组合根除幽门螺杆菌(Hp)的疗效及安全性。方法:选择286例Hp阳性的消化性溃疡病(PUD)患者,随机分为4组,以质子泵抑制剂(奥美拉唑)为基础。A组:阿莫西林+左氧氟沙星;B组:阿莫西林+呋喃唑酮;C组:阿莫西林+甲硝唑;D组:阿莫西林+克拉霉素。疗程1周,对比分析疗程结束后4周的Hp根除率、溃疡愈合率及不良反应发生率。结果:左氧氟沙星组的Hp根除率优于甲硝唑组及克拉霉素组,P<0.05;呋喃唑酮的Hp根除率优于甲硝唑组,P<0.05;4种治疗方案的溃疡愈合率比较差异无显著性,不良反应发生率比较差异无显著性。结论:奥美拉唑、阿莫西林、左氧氟沙星二联疗法Hp根除率高,不良反应少,值得推广。
作者 杨昆政 陈波
机构地区 西安市北方医院
出处 《中国社区医师(医学专业)》 2008年第15期49-49,共1页
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  • 1Malfertheiner P, Mégraud F, O Morain C, et al. Current concepts in the management of Helicobacter pylori infection-the Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther,2002,16:167-180.
  • 2Mégraud F, Hazell S, Glupczynski Y. Antibiotic susceptibility and resistance. In: Mobley HLT, Mendz GL, Hazell SL, eds.Helicobacter pylori: Physiology and Genetics. Washington DC:ASM Press,2001. 511-530.
  • 3Mégraud F. Helicobacter pylori and macrolides. In: Schonfeld W, Kirst HA, eds. Macrolide antibiotics. Berlin: Birkhauser,2002. 243-260.
  • 4Gisbert JP, Calvet X, Bujanda L, et al. Rescue' therapy with rifabutin after multiple Helicobacter pylori treatment failures.Helicobacter, 2003,8: 90-94.
  • 5Masconi G, Parente F, Russo A, et al. Do some patients with Helicobacter pylori infection benefit from an extension to 2 weeks of a proton pump inhibitor-based triple eradication therapy? Am J Gastroenterol, 2001,96: 359-366.
  • 6Baena JM, Lopez C, Hidalgo A, et al. Relation between alcohol consumption and the success of Helicobacter pylori eradication therapy using omeprazole, clarithromycin and amoxicillin for 1 week. Eur J Gastroenterol Hepatol, 2002,14: 291-296.
  • 7Amieva MR, Salama NR, Tompkins LS, et al. Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells. Cell Microbiol, 2002,4 : 677-690.
  • 8Matysiak-Budnik T, Heyman M, Candalh C, et al. In vitro transfer of clarithromycin and amoxicillin across the epithelial barrier. J Antimicrob Chemother, 2002,50: 865-872.
  • 9Rabelo-Goncalves EM, Nishimura NF, Zeitune JM. Acute inflammatory response in the stomach of BALB/c mice chal lenged with coccoidal Helicobacter pylori. Mem Inst Oswaldo Cruz,2002,97:1201-1206.
  • 10Broutet N, Tchamgoué S, Pereira E, et al. Risk factors for failure of Helicobacter pylori therapy. Results of an individual data analysis of 2751 patients. Aliment Pharmacol Ther, 2003,17:99-109.

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