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分娩启动时母体免疫功能变化

Change in T lymphocyte subsets during the onset of normal labor
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摘要 目的:探讨分娩启动时母体免疫功能变化。方法:采用血液自动分析仪和流式细胞仪检测15例分娩发动妇女、15例正常妊娠早期妇女和12例正常育龄妇女的外周血中淋巴细胞和粒细胞百分率以及T淋巴细胞及其亚群的百分率。结果:(1)3组间比较,分娩发动组和正常妊娠早期组白细胞总数显著高于正常未孕组(P均<0.05);其中分娩发动组淋巴细胞百分数显著高于正常妊娠早期妇女(P<0.05),接近正常未孕水平(P>0.05);分娩发动组和正常妊娠早期妇女粒细胞百分数明显低于正常未孕妇女(P<0.05)。(2)与正常妊娠早期妇女相比,分娩发动组CD3+细胞为(68.08±6.87),显著高于正常妊娠早期妇女的(56.69±11.22),P<0.05,与正常未孕妇女(61.23±7.92)相比,差异无统计学意义;分娩发动组和正常未孕妇女CD4+细胞的百分率以及CD4+/CD8+的比值分别为(40.87±6.63)、(1.58±0.44)和(38.36±8.44)、(1.63±0.52),均显著高于正常妊娠早期妇女的(30.34±7.05)、(1.13±0.32)(P均<0.05),而分娩发动组和正常未孕妇女相比,无显著差异(P>0.05);CD8+细胞的百分率3组之间相比无显著差异(P均>0.05)。结论:分娩发动时CD4+细胞数增加使CD4+/CD8+细胞比例失调,提示免疫因素在分娩启动时起着重要作用。 Objective:To investigate the change in T lymphocyte subsets of peripheral blood during onset of normal labor.Methods:Blood leukocyte population and the percentage of lymphocyte subsets in 15 gravid women at the time of labor onset, 15 pregnant women in the first trimester and 12 non-pregnant women were repectively detected by an automatic blood corpuscle counter and flowcytometry. Results: (1)The lymphocyte percentage in leucocytes of peripheral blood was notably higher in the women with labor onset than in early normal pregnant women (P〈0.05).(2)The percentage of CD3^+ T cells in the peripheral blood was remarkably increased in the labor onset group compared with that in early normal pregnant women (68.08±6.87 VS 56.69±11.22 ,P=0.017), there was no difference between labor onset group and non-pregnant group (P〉0.05). The percentage of CD4^+ T cells and the value CD4^+/CD8^+ in the peripheral blood were dramaticly increased in labor onset group and non-pregnant group compared with those in early normal pregnant women (40.87±6.63 and 38.36 ±8.44 VS 30.34±%05,1.58±0.44 and 1.63±0.52 VS 1.13±0.32,respectively).There was no marked difference in CD8^+cells among them (27.20±6.16 and 24.03±4.83 VS 26.36±5.06 ,P〉0.05).Conclusion:These results show that the occurrence of labor onset may be associated with the increase of CD4 positive cells.Thus, the increase of CIM positive cells may be one of important factors inducing labor onset.
出处 《现代医药卫生》 2008年第15期2222-2224,共3页 Journal of Modern Medicine & Health
基金 镇江市科技局社会发展项目(编号SH2007040)
关键词 分娩发动 母体免疫功能 T淋巴细胞亚群 Labor onset Maternal immune function T lymphocyte subsets
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参考文献7

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二级参考文献3

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