滋阴补肾丸对广防己减毒作用的初步研究

Preliminary Study on Reducing Poisonous Effects of Ziyin Bushen Pill to Aristolochia Fangchi

目的通过研究滋阴补肾丸对广防己中马兜铃酸A含量的影响,探讨广防己的解毒问题。方法广防己与滋阴补肾丸共煎后,采用RP-HPLC法测定马兜铃酸A的吸收值,观测其含量的变化情况。结果加入滋阴补肾丸后,广防己中马兜铃酸A的含量明显降低。结论滋阴补肾丸可显著降低广防己中马兜铃酸A的含量。

Objective To study the effects of Ziyin Bushen Pill on Aristolochia acid A in Aristolochia fangchi, and preliminary study on reducing poisonous effects of Ziyin Bushen Pill to Aristolochia fangchi. Methods Absorption of Aristolochhia acid A in the mingled decoction of Aristolochia fangchi and Ziyin Bushen Pill by HPLC, and the change of Aristolochia acid A was observed. Results Aristolochia acid A content of Aristolochia fangchi was markedly decreased after Ziyin Bushen Pill was added. Conclusion Ziyin Bushen Pill can markedly decreased Aristolochhia acid A content of Aristolochia fangchi.