多指标综合评分法优化更年康颗粒醇提工艺

Optimization of the Extraction Technology for Gengniankang Granules with the Multiple Guidelines Grading Method

目的优化更年康颗粒的醇提工艺。方法采用正交试验设计,以芍药苷、黄芪甲苷含量为评定指标,用多指标综合评分法进行数据处理,优化提取条件。结果更年康颗粒优化醇提工艺为18倍量70%乙醇,分3次回流提取,每次1.5 h。结论该提取工艺合理,有效成分提取效率高。

Objective To optimize the extraction technology for GengnianKang Granules.Methods An orthogonal test was adopted in the study. The contents of Paeoniflorin and Astragaloside Ⅳ were used as indices of appraisal. Data processing was carried out with the multiple guidelines grading method for optimizing the extraction condition. Results The optimized extraction technology for Gengniankang Granules was shown to be： eighteen fold volume of 70% alcohol should be added to 1 volume of the granules for 3 successive reflux extractions with 1.5 h of each. Conclusion The optimized extraction technology was rational and the extraction rate of the active components was high.