表皮生长因子受体、多胺与肺癌的关系

Epidermal Growth Factor Receptor and Polyamine in Primary Human Lung Cancer

探讨表皮生长因子受体（ＥＧＦＲ）和多胺（ＰＡ）对人肺癌及正常肺组织生长、分化的影响。方法放射性配体结合法检测ＥＧＦＲ含量；高效液相色谱分析法测ＰＡ含量。结果肺癌组织中ＥＧＦＲ的含量（５．６２±４．２６ｆｍｏｌ／ｍｇ膜蛋白）高于非癌肺组织（３．９０５±２．２７９ｆｍｏｌ／ｍｇ膜蛋白），有显著性差异（Ｐ＜０．０１）；肺癌组织ＰＡ的含量亦高于正常肺组织（Ｐ＜０．０１）。结论ＥＧＦＲ和ＰＡ可促使肺癌发展。

Objective To investigate the effect of epidermal growth factor receptors and polyamine (PA) on the growth and differentiation of lung cancer tissue and normal lung tissue in the same individual. Methods Epidermal growth factor receptors were measured radioligand binding assay. A highperformance liquid chromatrographiy by was used for the determination of polyamine. Results The EGFR contents were higher in lung cancer tissues (5.62±4.26 f mol/mg membrane protein) than that in normal tissues from the same patient (3.905±2.279 f mol/mg membrane protein) (P<0.01). PA contents were also higher in lung cancer tissues than that in normal tissues with,a highly significant difference (P<0.01). Conclusion The results show that EGFR and PA can promote the development of lung cancer and might be a tumor marker of cancer of the lung.