摘要
为观察消炎痛对梗阻性黄疸(梗黄)肾功能的影响,采用放射免疫测定法(RIA)检测20例服用消炎痛的梗黄患者服药前后及术后第4天血浆血栓素(TXA2)、前列环素(PGI2)和肾功能,并计算TXA2/PGI2比值。结果表明:服用消炎痛后随着TXA2/PGI2的下降(P<0.001),血清β2—微球蛋白(β2—MG)亦有明显下降(P<0.05),但不能恢复至正常水平。提示消炎痛可通过抑制TXA2生成,在一定范围内改善梗黄的肾功能损害。
In order to study the effects of indomethacin on renal function of obstructive jaundice,serum β2 - Microglobin (β2- MG) and urinary β2 levels in 20 cases of obstructive jaundice were measured by radioimmunoassay before and 3 days after they took indomethacin orally. Plasma thromboxane (TXA2) and prostacyclin (PGI2) were also determined in the meanwhile. As results,indomethacin decreased significantly both TXA2/PGI2 (P<0.001 ) and serum β2 -MG levels (P<0.05). The study suggest that indomethacin may improve renal dysfunction of obstructive jaundice to a certain extent by inhibiting TXA2 systhesis.
出处
《肝胆外科杂志》
1997年第5期290-292,共3页
Journal of Hepatobiliary Surgery
关键词
消炎痛
梗阻性黄疸
肾功能损害
临床研究
Indomethacin Obstructive jaundice Renal dysfunction Thromboxane Prostacyclin