消炎痛改善梗阻性黄疸肾功能损害的临床研究

A Clinical study on indomethacin improving renal dysfunction of obstuction jaundice

为观察消炎痛对梗阻性黄疸（梗黄）肾功能的影响，采用放射免疫测定法（RIA）检测20例服用消炎痛的梗黄患者服药前后及术后第4天血浆血栓素（TXA2）、前列环素（PGI2）和肾功能，并计算TXA2／PGI2比值。结果表明：服用消炎痛后随着TXA2／PGI2的下降（P＜0.001），血清β2—微球蛋白（β2—MG）亦有明显下降（P＜0．05），但不能恢复至正常水平。提示消炎痛可通过抑制TXA2生成，在一定范围内改善梗黄的肾功能损害。

In order to study the effects of indomethacin on renal function of obstructive jaundice,serum β2 - Microglobin (β2- MG) and urinary β2 levels in 20 cases of obstructive jaundice were measured by radioimmunoassay before and 3 days after they took indomethacin orally. Plasma thromboxane (TXA2) and prostacyclin (PGI2) were also determined in the meanwhile. As results,indomethacin decreased significantly both TXA2/PGI2 (P<0.001 ) and serum β2 -MG levels (P<0.05). The study suggest that indomethacin may improve renal dysfunction of obstructive jaundice to a certain extent by inhibiting TXA2 systhesis.