注射用泮托拉唑治疗上消化道出血的临床疗效

Clinical observation of pantoprazole for injection in the treatment of upper gastrointestinal bleeding

目的:观察泮托拉唑治疗上消化道出血的临床疗效并探讨其安全性。方法:98例上消化道出血患者随机分为观察组50例和对照组48例,分别给与注射用泮托拉唑和注射用奥美拉唑40mg静脉滴注,2次/d,疗程3d;观察两组36h及72h的临床症状改善及镜下止血情况。结果:观察组与对照组显效率分别为64.00%,64.58%,总有效率分别为96.00%,93.75%,两组比较差异无显著性(P>0.05)。两组均未见明显不良反应。结论:注射用泮托拉唑治疗上消化道出血疗效肯定,不良反应轻微,适合临床应用。

OBJECTIVE To research the clinical effect and safety of pantoprazole in the treatment of upper gastrointestinal bleeding. METHODS 98 patients with upper gastrointestinal bleeding were randomly divided into 2 groups,48 cases in the control group were given with omeprazole 40 mg （iv,bid,3 days） ;50 cases in the treating group were given with pantoprazole 40 mg （iv, bid, 3 days）. To observe the clinical symptom amelioration after 36 h and 72 h, and hemostasis sign under the endoscope. RESULTS After treatment, the total utility rate for the treating and control group of patients were 96. 00% and 93.75%. There was no significant difference between two groups （P〉0.05）. The biochemical indicator of 2 groups patients had no changes after treatment. And 2 groups patients had no adverse effect of drug. CONCLUSION Pantoprazole is an effective drug with fewer side effect for treatment of upper gastrointestinal bleeding.