660例抗癫痫药血药浓度监测分析

Retrospective analysis on anti-epilepsy drugs serum concentration in 660 cases

目的:分析3种常用抗癫痫药的血药浓度监测情况,指导患者合理用药。方法:采用高效液相色谱法测定卡马西平和苯巴比妥血药浓度;采用气相色谱法测定丙戊酸的血药浓度。结果:共监测660例次,达到有效治疗浓度者为62.12%;低于有效治疗浓度者为26.97%;高于有效治疗浓度者10.91%;结论:血药浓度监测结果是指导临床用药的依据之一,血药浓度不在治疗窗内的原因很多,应结合其他临床指标综合分析监测结果。

OBJECTIVE In order to guide the rational administration in clinic,the results of monitoring anti-epilepsies drugs serum concentration in 660 cases were analyzed. METHODS The serum concentration of carbamazepine and phenobarbital were determined by HPLC,and valproic acid was determined by HPGC. RESULTS All children were below 17 years old. 62, 12% of serum concentrations were in therapeutic window in 660 cases. 26. 97% of serum concentrations were less than therapeutic window, 10.91 % of serum concentrations were more than therapeutic window, CONCLUSION Serum drug concentration is important to guide the rational administration. However, it should be combined with other clinical data to evaluate the efficacy of anti epilepsy drugs due to various factors.