摘要
目的:考察注射用炎琥宁与注射用头孢曲松钠在0.9%氯化钠注射液中的配伍稳定性。方法:采用高效液相色谱法,以Venusil XBP-C_(18)色谱柱,乙腈-0.02 mol·L^(-1)磷酸二氢钾-10%四丁基氢氧化铵(pH 5.0)(38:60.5:1.5)为流动相,252 nm为检测波长,测定注射用炎琥宁与注射用头孢曲松钠配伍后在室温下6 h内的含量变化,并观察和检测配伍液的外观及pH值变化。结果:配伍液pH值及含量无明显变化,但颜色随时间变化逐渐加深。结论:注射用炎琥宁与注射用头孢曲松钠在0.9%氯化钠注射液可配伍使用,但应在4 h内用完。
Objective: To study the stability of the mixture of potassium sodium dehydroandrographolide succinate for injection with ceftriaxon injection in 0.9% sodium chloride injection. Method: HPLC method was adopted in which the Venusil XBP-C18 was used as the chromatographic column, acetonitrile-0.02 mol· L-1 potassium dihydrogen phosphate -10% tetrabutylammonium hydroxide solution ( pH 5.0) (38:60.5: 1.5 ) as the mobile phase with detection wavelength at 252 nm. The contents were determined after mixing of potassium sodium dehydroandrographolide succinate with ceftriaxon injection in 0.9% sodium chloride injection under the room temperature within 6 hours, and the appearance of the solution was observed and its pH value was determined. Result: No significant differences were found In terms of pH value and the contents of the mixed solution, but The colour changes as necessary gradually deepens. Conclusion: The mixture of potassium sodium dehydroandrographolide succinate with ceftriaxon injection in 0.9% sodium chloride injection can be used at room temperature, but must be injected during 4 hours.
出处
《中国药师》
CAS
2008年第8期928-930,共3页
China Pharmacist
关键词
高效液相色谱法
炎琥宁
头孢曲松钠
配伍
稳定性
HPLC
Potassium sodium dehydroandrographolide succinate for injection
Ceftriaxon
Compatibility
Stability